公开(公告)号：US12013521B2

公开(公告)日：2024-06-18

申请号：US17353901

申请日：2021-06-22

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Jay Shafto ,  Joyce Huang ,  Ziyi Wu

IPC: C12Q1/6869 ,  G02B21/00 ,  G02B21/02 ,  G02B21/24 ,  G02B21/33

CPC classification number: G02B21/008 ,  G02B21/0036 ,  G02B21/02 ,  G02B21/24 ,  G02B21/33

Abstract: Embodiments of the disclosure include methods and systems for nucleic acid sequencing that may include an objective coupled to an actuator, wherein the actuator is configured to move the objective over a surface of a substrate. In some embodiments, a droplet may be disposed on the surface of the substrate, and the droplet may be moved along with the objective. The distal end of the objective may include a material that provides a higher friction against the droplet than a material of the surface of the substrate. In some embodiments, the distal end of the objective may be immersed in a fluid as it is moved over the surface of the substrate. The substrate may include vertical walls within a region to retain the fluid.

公开(公告)号：US20210405337A1

公开(公告)日：2021-12-30

申请号：US17353901

申请日：2021-06-22

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Jay Shafto ,  Joyce Huang ,  Ziyi Wu

IPC: G02B21/00 ,  G02B21/02 ,  G02B21/33 ,  G02B21/24

Abstract: Embodiments of the disclosure include methods and systems for nucleic acid sequencing that may include an objective coupled to an actuator, wherein the actuator is configured to move the objective over a surface of a substrate. In some embodiments, a droplet may be disposed on the surface of the substrate, and the droplet may be moved along with the objective. The distal end of the objective may include a material that provides a higher friction against the droplet than a material of the surface of the substrate. In some embodiments, the distal end of the objective may be immersed in a fluid as it is moved over the surface of the substrate. The substrate may include vertical walls within a region to retain the fluid.

公开(公告)号：US12235216B2

公开(公告)日：2025-02-25

申请号：US17798786

申请日：2020-02-12

Applicant: MGI Tech Co., Ltd.

Inventor： Heming Jiang ,  Yi Huang ,  Qian Deng ,  Bin Yang ,  Xin Wen ,  Mingyou Cao ,  Yanqiao Huang ,  Ziyi Wu ,  Craig Edward Uhrich ,  Brian Keith Hauser ,  Chintang Yen

IPC: G01N21/64

Abstract: An optical imaging system (1) is configured for photographing a sample and includes a lighting module (11) and an imaging module (15). The lighting module (11) is configured for outputting excitation light, the excitation light is configured to excite the sample to generate excited light, the imaging module (15) comprises a time delay integration line scan camera (151), the time delay integration line scan camera (151) is configured to record the excited light. A biochemical substance detection system using the optical imaging system (1) is also provided, improving the detection flux.

公开(公告)号：US20240210669A1

公开(公告)日：2024-06-27

申请号：US18601187

申请日：2024-03-11

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Jay Shafto ,  Joyce Huang ,  Ziyi Wu

IPC: G02B21/00 ,  G02B21/02 ,  G02B21/24 ,  G02B21/33

CPC classification number: G02B21/008 ,  G02B21/0036 ,  G02B21/02 ,  G02B21/24 ,  G02B21/33

Abstract: Embodiments of the disclosure include methods and systems for nucleic acid sequencing that may include an objective coupled to an actuator, wherein the actuator is configured to move the objective over a surface of a substrate. In some embodiments, a droplet may be disposed on the surface of the substrate, and the droplet may be moved along with the objective. The distal end of the objective may include a material that provides a higher friction against the droplet than a material of the surface of the substrate. In some embodiments, the distal end of the objective may be immersed in a fluid as it is moved over the surface of the substrate. The substrate may include vertical walls within a region to retain the fluid.