公开(公告)号：US08704171B2

公开(公告)日：2014-04-22

申请号：US13682379

申请日：2012-11-20

Applicant: MKS Instruments, Inc.

Inventor： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC: G01N27/62

CPC classification number: G01N27/62 ,  G01N33/497 ,  H01J49/105 ,  Y10T436/24

Abstract: A system and methods are described for generating reagent ions and product ions for use in a mass spectrometry system. Applications for the system and method are also disclosed for detecting volatile organic compounds in trace concentrations. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass and peak intensity values for ion species during spectrometry and faults within the system.

Abstract translation: 描述了用于产生用于质谱系统的试剂离子和产物离子的系统和方法。 还公开了用于检测痕量浓度的挥发性有机化合物的系统和方法的应用。 微波或高频RF能源将试剂蒸气的颗粒电离以形成试剂离子。 试剂离子进入诸如漂移室的室以与流体样品相互作用。 电场引导试剂离子并促进与流体样品的相互作用以形成产物离子。 然后试剂离子和产物离子在电场的影响下离开室，由质谱模块检测。 该系统包括用于设置系统参数值和分析模块的各种控制模块，用于在光谱测定和系统内的故障期间检测离子种类的质量和峰值强度值。

公开(公告)号：US20130203180A1

公开(公告)日：2013-08-08

申请号：US13682379

申请日：2012-11-20

Applicant: MKS INSTRUMENTS, INC.

Inventor： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC: G01N27/62

CPC classification number: G01N27/62 ,  G01N33/497 ,  H01J49/105 ,  Y10T436/24

Abstract: A system and methods are described for generating reagent ions and product ions for use in a mass spectrometry system. Applications for the system and method are also disclosed for detecting volatile organic compounds in trace concentrations. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass and peak intensity values for ion species during spectrometry and faults within the system.

Abstract translation: 描述了用于产生用于质谱系统的试剂离子和产物离子的系统和方法。 还公开了用于检测痕量浓度的挥发性有机化合物的系统和方法的应用。 微波或高频RF能源将试剂蒸气的颗粒电离以形成试剂离子。 试剂离子进入诸如漂移室的室以与流体样品相互作用。 电场引导试剂离子并促进与流体样品的相互作用以形成产物离子。 然后试剂离子和产物离子在电场的影响下离开室，由质谱模块检测。 该系统包括用于设置系统参数值和分析模块的各种控制模块，用于在光谱测定和系统内的故障期间检测离子物质的质量和峰值强度值。