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公开(公告)号：US09494579B2
公开(公告)日：2016-11-15
申请号：US14481044
申请日：2014-09-09
Applicant: Massachusetts Institute of Technology
Inventor： Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
CPC classification number: G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
Abstract translation: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地，该方法提供了可溶性蛋白质和化学物质的检测。 此外，本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的靶颗粒，其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。
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公开(公告)号：US20150093745A1
公开(公告)日：2015-04-02
申请号：US14540273
申请日：2014-11-13
Applicant: Massachusetts Institute of Technology
Inventor： James Douglas Harper , Richard Hart Mathews , Bernadette Johnson , Martha Susan Petrovick , Ann Rundell , Frances Ellen Nargi , Timothy Stephens , Linda Marie Mendenhall , Mark Alexander Hollis , Albert M. Young , Todd H. Rider , Eric David Schwoebel , Trina Rae Vian
IPC: G01N21/64 , G01N33/569 , G01N21/75 , G01N15/02
CPC classification number: G01N33/554 , G01N15/0205 , G01N21/07 , G01N21/64 , G01N21/6428 , G01N21/75 , G01N21/76 , G01N33/54373 , G01N33/54393 , G01N33/56983 , G01N33/582 , G01N2021/6439 , G01N2201/025 , G01N2201/061 , Y10S435/808 , Y10S436/805
Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.
Abstract translation: 本发明涉及用于检测一个或多个目标颗粒的光电子系统。 该系统包括反应室，样品收集器，光学检测器和含有细胞的储存器，每个细胞具有存在于每个细胞表面上并且对待检测的靶颗粒是特异性的受体，其中结合 受体的目标颗粒直接或间接激活报告分子，从而产生可测量的光信号。
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公开(公告)号：US20160161479A1
公开(公告)日：2016-06-09
申请号：US14538271
申请日：2014-11-11
Applicant: Massachusetts Institute of Technology
Inventor： James Douglas Harper , Richard Hart Mathews , Bernadette Johnson , Martha Susan Petrovick , Ann Rundell , Frances Ellen Nargi , Timothy Stephens , Linda Marie Mendenhall , Mark Alexander Hollis , Albert M. Young , Todd H. Rider , Eric David Schwoebel , Trina Rae Vian
IPC: G01N33/554 , G01N33/543 , G01N21/07 , G01N21/76 , G01N21/64
CPC classification number: G01N33/554 , G01N15/0205 , G01N21/07 , G01N21/64 , G01N21/6428 , G01N21/75 , G01N21/76 , G01N33/54373 , G01N33/54393 , G01N33/56983 , G01N33/582 , G01N2021/6439 , G01N2201/025 , G01N2201/061 , Y10S435/808 , Y10S436/805
Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.
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公开(公告)号：US20150050723A1
公开(公告)日：2015-02-19
申请号：US14481044
申请日：2014-09-09
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Eric D. Schwoebel , James D. Harper , Martha S. Petrovick , Frances E. Nargi , Todd H. Rider , Kristine E. Hogan , Richard H. Mathews , Joseph Lacirignola , Mark Hennessy , Trina R. Vian , Rose M. Joseph , Raymond S. Uttaro , Shaun Berry , Bernadette Johnson , Mark A. Hollis
IPC: G01N33/53
CPC classification number: G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
Abstract translation: 本文描述的本发明提供了用于检测可溶性抗原的方法。 特别地，该方法提供了可溶性蛋白质和化学物质的检测。 此外，本发明提供了检测样品中核酸序列的方法。 还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的靶颗粒，其中待检测的靶颗粒被一种或多种抗体结合。 还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。
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