公开(公告)号：US20160161479A1

公开(公告)日：2016-06-09

申请号：US14538271

申请日：2014-11-11

Applicant: Massachusetts Institute of Technology

Inventor： James Douglas Harper ,  Richard Hart Mathews ,  Bernadette Johnson ,  Martha Susan Petrovick ,  Ann Rundell ,  Frances Ellen Nargi ,  Timothy Stephens ,  Linda Marie Mendenhall ,  Mark Alexander Hollis ,  Albert M. Young ,  Todd H. Rider ,  Eric David Schwoebel ,  Trina Rae Vian

IPC: G01N33/554 ,  G01N33/543 ,  G01N21/07 ,  G01N21/76 ,  G01N21/64

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

公开(公告)号：US09604169B2

公开(公告)日：2017-03-28

申请号：US14664771

申请日：2015-03-20

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Thomas Sebastian ,  Timothy Stephens

IPC: B01D45/08 ,  G01N1/40 ,  G01N15/00

CPC classification number: B01D45/08 ,  G01N1/40 ,  G01N1/4077 ,  G01N2015/0046

Abstract: A discrete bypass particle concentrator can significantly reduce surface fouling and manufacturing cost by including bypass stages after each of concentration stages.

公开(公告)号：US20150093745A1

公开(公告)日：2015-04-02

申请号：US14540273

申请日：2014-11-13

Applicant: Massachusetts Institute of Technology

Inventor： James Douglas Harper ,  Richard Hart Mathews ,  Bernadette Johnson ,  Martha Susan Petrovick ,  Ann Rundell ,  Frances Ellen Nargi ,  Timothy Stephens ,  Linda Marie Mendenhall ,  Mark Alexander Hollis ,  Albert M. Young ,  Todd H. Rider ,  Eric David Schwoebel ,  Trina Rae Vian

IPC: G01N21/64 ,  G01N33/569 ,  G01N21/75 ,  G01N15/02

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

Abstract translation: 本发明涉及用于检测一个或多个目标颗粒的光电子系统。 该系统包括反应室，样品收集器，光学检测器和含有细胞的储存器，每个细胞具有存在于每个细胞表面上并且对待检测的靶颗粒是特异性的受体，其中结合 受体的目标颗粒直接或间接激活报告分子，从而产生可测量的光信号。