公开(公告)号：US20180008687A1

公开(公告)日：2018-01-11

申请号：US15584516

申请日：2017-05-02

Applicant: Massachusetts Institute of Technology

Inventor： Paiman Peter Ghoroghchian ,  Ruogu Qi ,  Angela M. Belcher ,  Xiangnan Dang ,  Zhimin Tao

IPC: A61K39/00 ,  A61K47/10 ,  A61K47/34 ,  G01N21/47 ,  C12N15/09

Abstract: Disclosed are methods of treating cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents. In addition, nanoparticles are described that comprise a highly toxic anticancer agent (e.g., an anticancer agent having an IC50 less than 1 nM) covalently bound via a linker to a triblock copolymer. Other nanoparticles that comprise Pt(IV) and an anticancer agent are also described. Also disclosed are nanoparticles comprising imaging agents non-covalently associated with a polymer, and methods of imaging cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents.

公开(公告)号：US10751423B2

公开(公告)日：2020-08-25

申请号：US15584516

申请日：2017-05-02

Applicant: Massachusetts Institute of Technology

Inventor： Paiman Peter Ghoroghchian ,  Ruogu Qi ,  Angela M. Belcher ,  Xiangnan Dang ,  Zhimin Tao

IPC: A61K9/00 ,  A61K48/00 ,  A61K47/60 ,  A61K47/64 ,  A61K47/69 ,  A61K31/555 ,  A61K33/24 ,  C08G81/00 ,  C12N15/11 ,  A61K9/107 ,  A61K31/282 ,  A61K47/34 ,  C07K2/00 ,  C08G69/10 ,  C12N15/90 ,  A61K39/00 ,  A61K47/10 ,  C12N15/09 ,  G01N21/47

Abstract: Disclosed are methods of treating cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents. In addition, nanoparticles are described that comprise a highly toxic anticancer agent (e.g., an anticancer agent having an IC50 less than 1 nM) covalently bound via a linker to a triblock copolymer. Other nanoparticles that comprise Pt(IV) and an anticancer agent are also described. Also disclosed are nanoparticles comprising imaging agents non-covalently associated with a polymer, and methods of imaging cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents.