公开(公告)号：US11122979B2

公开(公告)日：2021-09-21

申请号：US16289529

申请日：2019-02-28

Applicant: MediBeacon Inc.

Inventor： Ralf Heinrich ,  Johannes Pill ,  Sabine Neudecker ,  Daniel Schock-Kusch ,  Juergen Guenther ,  Stefan Koenig ,  Jochen Friedemann

IPC: A61B5/00 ,  A61B5/20 ,  A61B5/1455

Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.

公开(公告)号：US20230132361A9

公开(公告)日：2023-04-27

申请号：US17401866

申请日：2021-08-13

Applicant: MediBeacon Inc.

Inventor： Ralf Heinrich ,  Johannes Pill ,  Sabine Neudecker ,  Daniel Schock-Kusch ,  Juergen Guenther ,  Stefan Koenig ,  Jochen Friedemann

IPC: A61B5/00 ,  A61B5/20 ,  A61B5/1455

Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.

公开(公告)号：US20220022753A1

公开(公告)日：2022-01-27

申请号：US17401866

申请日：2021-08-13

Applicant: MediBeacon Inc.

Inventor： Ralf Heinrich ,  Johannes Pill ,  Sabine Neudecker ,  Daniel Schock-Kusch ,  Juergen Guenther ,  Stefan Koenig ,  Jochen Friedemann

IPC: A61B5/00 ,  A61B5/20 ,  A61B5/1455

Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.

公开(公告)号：US20250102438A1

公开(公告)日：2025-03-27

申请号：US18897554

申请日：2024-09-26

Applicant: MediBeacon Inc.

Inventor： Jesse Ross-Jones ,  Jochen Friedemann

IPC: G01N21/64

Abstract: Method, system, and apparatus determines glomerular filtration rate (GFR) by obtaining a measurement data set. Furthermore, the disclosure includes obtaining a measurement data set comprising a plurality of measurement entries that are obtained before and after administration of an exogenous fluorescent agent; generating an intrinsic fluorescence (IF) signal representing a detected fluorescence intensity emitted by the exogenous fluorescent agent from within a diffuse reflecting medium; determining if the IF signal includes a portion of premature fluorescence data; identifying, upon determination of the portion of premature fluorescence data, an operable IF signal range by filtering the IF signal associated with premature fluorescence data; determining a GFR value in the patient based on a rate of change of the operable IF signal; providing the GFR value.

公开(公告)号：US12257027B2

公开(公告)日：2025-03-25

申请号：US17401866

申请日：2021-08-13

Applicant: MediBeacon Inc.

Inventor： Ralf Heinrich ,  Johannes Pill ,  Sabine Neudecker ,  Daniel Schock-Kusch ,  Juergen Guenther ,  Stefan Koenig ,  Jochen Friedemann

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/20

Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.

公开(公告)号：US20190261862A1

公开(公告)日：2019-08-29

申请号：US16289529

申请日：2019-02-28

Applicant: MediBeacon Inc.

Inventor： Ralf Heinrich ,  Johannes Pill ,  Sabine Neudecker ,  Daniel Schock-Kusch ,  Juergen Guenther ,  Stefan Koenig ,  Jochen Friedemann

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/20

Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.