公开(公告)号：US20180214057A1

公开(公告)日：2018-08-02

申请号：US15884365

申请日：2018-01-30

Applicant: MediBeacon Inc.

Inventor： Kimberly Schultz ,  Jennifer Keating ,  Edward Solomon ,  Kate Bechtel

IPC: A61B5/1455 ,  G01J1/44 ,  G01J1/04 ,  A61B5/00

Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light. The method further includes identifying a post-agent administration portion of the measurement data set; and transforming each Flr signal to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent.

公开(公告)号：US10548521B2

公开(公告)日：2020-02-04

申请号：US15884365

申请日：2018-01-30

Applicant: MediBeacon Inc.

Inventor： Kimberly Schultz ,  Jennifer Keating ,  Edward Solomon ,  Kate Bechtel

IPC: G06F11/30 ,  A61B5/1455 ,  G01J1/44 ,  A61B5/00 ,  G01J1/04

Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light. The method further includes identifying a post-agent administration portion of the measurement data set; and transforming each Flr signal to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent.