公开(公告)号：US11104901B2

公开(公告)日：2021-08-31

申请号：US16796034

申请日：2020-02-20

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Ke Zhang ,  Xueguang Lu

IPC: C12N15/113 ,  A61K49/00 ,  C12Q1/6886 ,  G06F9/48 ,  G06F9/50

Abstract: The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a non-cationic, sterically congested brush polymer and the use of such polymer-oligonucleotide conjugates in antisense gene regulation and as diagnostic agents.

公开(公告)号：US10590414B2

公开(公告)日：2020-03-17

申请号：US15750360

申请日：2016-08-04

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Ke Zhang ,  Xueguang Lu

IPC: C12N15/113 ,  A61K49/00 ,  C12Q1/6886

Abstract: The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a non-cationic, sterically congested brush polymer and the use of such polymer-oligonucleotide conjugates in antisense gene regulation and as diagnostic agents.