公开(公告)号：US20220010302A1

公开(公告)日：2022-01-13

申请号：US17046482

申请日：2019-04-12

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Gokay Yamankurt ,  Milan Mrksich ,  Eric J. Berns ,  Neda Bagheri ,  Albert Xue ,  Andrew Lee

IPC: C12N15/10

Abstract: The present disclosure provides methods for the rapid synthesis of large libraries of spherical nucleid acid (SNA) nanoparticles, their screening for activity, and a machine learning algorithm to analyze the data.

公开(公告)号：US11150185B2

公开(公告)日：2021-10-19

申请号：US16017766

申请日：2018-06-25

Applicant: Northwestern University

Inventor： Chen He ,  David J. Weinberg ,  Emily A. Weiss ,  Jeremiah Yoonsung Kim ,  Chen Wang ,  Andrew Lee

IPC: B82Y15/00 ,  B82Y20/00 ,  B82Y40/00 ,  G01N21/64 ,  H01L51/50 ,  C01G21/21

Abstract: The present technology is directed to the nanoparticles for use as molecular environmental sensors. The nanoparticles comprise a photoluminescence core and a plurality of ligands bound to the core and forming a quencher permeable ligand shell. The ligands comprise a reactive or charged moiety capable of being modulated between a first stand and a second state, and the proportion of ligands in each state determine the permeability of the ligand shell to a photoluminescence quencher.

公开(公告)号：US11796472B2

公开(公告)日：2023-10-24

申请号：US17505392

申请日：2021-10-19

Applicant: Northwestern University

Inventor： Chen He ,  David J. Weinberg ,  Emily A. Weiss ,  Jeremiah Yoonsung Kim ,  Chen Wang ,  Andrew Lee

IPC: G01N21/64 ,  C01G21/21 ,  H10K50/115 ,  B82Y40/00 ,  B82Y20/00 ,  B82Y15/00

CPC classification number: G01N21/6428 ,  C01G21/21 ,  G01N21/6489 ,  H10K50/115 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y40/00 ,  C01P2004/64 ,  G01N2021/6432

Abstract: The present technology is directed to the nanoparticles for use as molecular environmental sensors. The nanoparticles comprise a photoluminescence core and a plurality of ligands bound to the core and forming a quencher permeable ligand shell. The ligands comprise a reactive or charged moiety capable of being modulated between a first stand and a second state, and the proportion of ligands in each state determine the permeability of the ligand shell to a photoluminescence quencher.

公开(公告)号：US10688195B2

公开(公告)日：2020-06-23

申请号：US16083357

申请日：2017-03-17

Applicant: Northwestern University ,  Midwestern University

Inventor： Alan R. Hauser ,  Andrew Lee ,  Marc H. Scheetz ,  Nathaniel J. Rhodes

IPC: A61K47/69 ,  A61K47/20 ,  A61K9/14 ,  A61K9/51 ,  A61K47/10 ,  A61P31/04 ,  A61K31/43 ,  A61K38/12 ,  A61K38/14 ,  B82Y5/00

Abstract: Provided herein are antibiotic coated nanoparticles and methods of treating bacterial infection therewith. In particular embodiments, polymyxin B, vancomycin, and/or other antibiotics are linked to nanoparticles (e.g., gold or silica nanoparticles) and utilized for the treatment of bacterial infections.

公开(公告)号：US20190099500A1

公开(公告)日：2019-04-04

申请号：US16083357

申请日：2017-03-17

Applicant: Northwestern University ,  Midwestern University

Inventor： Alan R. Hauser ,  Andrew Lee ,  Marc H. Scheetz ,  Nathaniel J. Rhodes

IPC: A61K47/69 ,  A61K47/20 ,  A61K47/10 ,  A61K9/51

Abstract: Provided herein are antibiotic coated nanoparticles and methods of treating bacterial infection therewith. In particular embodiments, polymyxin B, vancomycin, and/or other antibiotics are linked to nanoparticles (e.g., gold or silica nanoparticles) and utilized for the treatment of bacterial infections.

公开(公告)号：US11433131B2

公开(公告)日：2022-09-06

申请号：US16611502

申请日：2018-05-11

Applicant: Northwestern University

Inventor： Chad A. Mirkin ,  Andrew Lee ,  Bin Zhang ,  Donye Dominguez

IPC: C07H21/04 ,  A61K39/39 ,  A61P35/00 ,  A61K39/00 ,  C12N15/113

Abstract: The disclosure is related to compositions comprising a cell and a spherical nucleic acid (SNA) comprising a nanoparticle, an oligonucleotide on the surface of the nanoparticle, and an antigen; and to methods for production of such compositions and their applications, including but not limited to adoptive cell therapy.

公开(公告)号：US20180372637A1

公开(公告)日：2018-12-27

申请号：US16017766

申请日：2018-06-25

Applicant: Northwestern University

Inventor： Chen He ,  David J. Weinberg ,  Emily A. Weiss ,  Jeremiah Yoonsung Kim ,  Chen Wang ,  Andrew Lee

IPC: G01N21/64 ,  H01L51/50

Abstract: The present technology is directed to the nanoparticles for use as molecular environmental sensors. The nanoparticles comprise a photoluminescence core and a plurality of ligands bound to the core and forming a quencher permeable ligand shell. The ligands comprise a reactive or charged moiety capable of being modulated between a first stand and a second state, and the proportion of ligands in each state determine the permeability of the ligand shell to a photoluminescence quencher.

公开(公告)号：US20160159834A1

公开(公告)日：2016-06-09

申请号：US14785867

申请日：2014-04-22

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Andrew Lee ,  Chad A. Mirkin ,  Colin Michael Calabrese ,  Natalia Chernyak ,  Evelyn Auyeung

IPC: C07F9/24 ,  C12N15/113 ,  C07H19/10

CPC classification number: C07F9/2408 ,  A61K9/14 ,  A61K9/5115 ,  C07F9/2412 ,  C07F9/2458 ,  C07F9/65586 ,  C07H19/073 ,  C07H19/10 ,  C07H21/00 ,  C07H21/04 ,  C12N15/111 ,  C12N15/113 ,  C12N15/87 ,  C12N2310/3515 ,  C12N2310/3519

Abstract: The present disclosure is directed to compositions comprising alkyne oligonucleotides, nanoconjugates prepared from the same, and methods of their use.

Abstract translation: 本公开涉及包含炔烃寡核苷酸，由其制备的纳结合物及其使用方法的组合物。