公开(公告)号：US20240024838A1

公开(公告)日：2024-01-25

申请号：US18224997

申请日：2023-07-21

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Kaitlin Marie Landy ,  Kyle Joseph Gibson

IPC: B01J13/00 ,  B22F1/054 ,  B22F1/17

CPC classification number: B01J13/0043 ,  B22F1/054 ,  B22F1/17 ,  B82Y40/00

Abstract: A method of making colloidal crystals using seed programmable atom equivalents (PAEs) and growth programmable atom equivalents (PAEs) for at least two stage growth. The seed and growth PAEs each include nanoparticles functionalized with oligonucleotides with sticky ends. Seed PAEs have sticky ends adapted to hybridize to each other to form a first duplex, and growth PAEs have sticky ends adapted to hybridize to a respective ones of the seed PAEs and to each other to form second, third, and fourth duplexes. Using base mismatches in the sticky ends of the growth PAEs and a two stage cooling, the first duplex having a higher melting temperature than the other duplexes nucleate the seed PAEs as seeds in a first stage and remaining duplexes form in a second lower temperature stage for growth on the seeds.

公开(公告)号：US20250043081A1

公开(公告)日：2025-02-06

申请号：US18717280

申请日：2022-12-05

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Max Everett Distler ,  Ho Fung Cheng ,  Kyle Joseph Gibson

IPC: C08G83/00 ,  C12N15/11

Abstract: The present disclosure is directed to multicomponent assemblies (e.g., crystalline structures) using oligonucleotide dendrimers and spherical nucleic acids (SNAs). The disclosure also provides methods of forming the multicomponent assemblies.