公开(公告)号：US20230382941A1

公开(公告)日：2023-11-30

申请号：US18225400

申请日：2023-07-24

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Katherine E. Bujold ,  Max Everett Distler

IPC: C07H19/04 ,  C07K14/705 ,  C12N15/117 ,  C07K16/00

CPC classification number: C07H19/04 ,  C07K14/705 ,  C12N15/117 ,  C07K16/00

Abstract: The present disclosure is directed to spherical nucleic acids (SNAs) comprising a nanoparticle core and an oligonucleotide dendron attached thereto. The disclosure also provides methods of using the SNAs for, for example, gene regulation and immune regulation.

公开(公告)号：US20250043081A1

公开(公告)日：2025-02-06

申请号：US18717280

申请日：2022-12-05

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Max Everett Distler ,  Ho Fung Cheng ,  Kyle Joseph Gibson

IPC: C08G83/00 ,  C12N15/11

Abstract: The present disclosure is directed to multicomponent assemblies (e.g., crystalline structures) using oligonucleotide dendrimers and spherical nucleic acids (SNAs). The disclosure also provides methods of forming the multicomponent assemblies.

公开(公告)号：US20220288181A1

公开(公告)日：2022-09-15

申请号：US17684269

申请日：2022-03-01

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Michelle Hope Teplensky ,  Max Everett Distler ,  Caroline Danielle Kusmierz ,  Cassandra Elizabeth Callmann

IPC: A61K39/00 ,  A61P35/00 ,  A61K39/39 ,  C12N15/113

Abstract: Spherical Nucleic Acids (SNAs) are chemically well-defined nanoscale architectures comprised of nucleic acids densely arranged around a spherical nanoparticle core in a highly oriented fashion. SNAs are highly modular structures produced by chemical synthesis and programmed assembly, allowing for their rapid modification to incorporate novel viral antigens. The present disclosure provides a SNA comprising (a) a nanoparticle core; (b) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more immunostimulatory oligonucleotides; and (c) a viral antigen encapsulated in the nanoparticle core.