公开(公告)号：US20030106799A1

公开(公告)日：2003-06-12

申请号：US10313231

申请日：2002-12-06

Applicant: Nanostream, Inc

Inventor： Joseph F. Covington ,  Steven E. Hobbs ,  Jeffrey A. Koehler ,  Paren P. Patel ,  Marci Pezzuto ,  Mark S. Scheib

IPC: G01N027/453

CPC classification number: B01L3/502707 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00891 ,  B01J2219/00952 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B29C65/18 ,  B29C66/02 ,  B29C66/026 ,  B29C66/1122 ,  B29C66/45 ,  B29C66/71 ,  B29C66/727 ,  B29C66/73112 ,  B29C66/8322 ,  B29C66/91212 ,  B29C66/91213 ,  B29C66/91216 ,  B29C66/91221 ,  B29C66/91231 ,  B29C66/91411 ,  B29C66/91445 ,  B29C66/91645 ,  B29C66/92445 ,  B29C66/929 ,  B29C66/961 ,  B29K2023/00 ,  B29K2023/12 ,  B29L2031/756 ,  B32B37/0023 ,  B32B37/08 ,  B32B37/10 ,  B32B38/004 ,  B32B41/00 ,  B32B2037/0092 ,  B32B2038/166 ,  B32B2309/02 ,  B32B2309/022 ,  B32B2309/12 ,  B32B2310/024 ,  B81B2201/058 ,  B81C1/00119 ,  B81C3/008 ,  B81C2201/019 ,  G01N27/44791 ,  G01N30/6095 ,  Y10T29/49002 ,  Y10T137/0402 ,  Y10T137/2224 ,  Y10T137/598 ,  B29C2035/0827 ,  B29K2067/00

Abstract: A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device layers, the device layers including a first cover layer, second cover layer, and at least one stencil layer defining a microfluidic channel penetrating through the entire thickness of the stencil layer also are provided. Each stencil layer is disposed between other device layers such that the channel is bounded laterally by a stencil layer, and bounded from above and below by surrounding device layers to define an upper channel surface and a lower channel surface. The device layers are stacked between the first platen and the second platen. The stacked device layers are controllably heated according to a heating profile adapted to form a substantially sealed adhesiveless microfluidic device wherein each upper channel surface remains distinct from its corresponding lower channel surface. The resulting microfluidic device has high inter-layer bond strength while preserving the integrity of the channel(s) defined in the stencil layer(s).

Abstract translation: 一种制造微流体装置的方法，其中设置有第一和第二基本平坦的压板。 还提供了多个基本平坦的，基本上无金属的无粘合剂聚合物器件层，所述器件层包括第一覆盖层，第二覆盖层和限定穿透模板层的整个厚度的微流体通道的至少一个模板层。 每个模版层设置在其它装置层之间，使得通道被模板层横向限定，并且由周围的装置层从上方和下方界定，以限定上通道表面和下通道表面。 装置层堆叠在第一压板和第二压板之间。 根据适于形成基本上密封的无粘合微流体装置的加热轮廓可控制地加热堆叠的装置层，其中每个上部通道表面保持与其相应的下部通道表面不同。 所得到的微流体装置具有高的层间结合强度，同时保持在模版层中定义的通道的完整性。