公开(公告)号：US10570444B2

公开(公告)日：2020-02-25

申请号：US15572296

申请日：2016-05-11

Applicant: Northeastern University

Inventor： Meni Wanunu ,  Joseph Larkin ,  Robert Henley

IPC: C12Q1/6869 ,  G02B6/10 ,  B82Y20/00

Abstract: Devices and methods useful for sequencing and characterizing single nucleic acid molecules involve large arrays of nanopore zero-mode waveguides (NZMWs). The methods and devices are made possible by fabrication of nanoporous membranes of appropriate porosity for use in nucleotide sequencing. The fabrication methods eliminate the need for serial nanopore formation and make possible the mass production of highly efficient DNA and RNA single molecule sequencing devices.

公开(公告)号：US10047392B2

公开(公告)日：2018-08-14

申请号：US15119859

申请日：2015-02-23

Applicant: Northeastern University

Inventor： Andrey Ivankin ,  Joseph Larkin ,  Robert Henley ,  Meni Wanunu

IPC: C12Q1/6869 ,  G01N21/64 ,  G01N33/487 ,  G01N21/77

Abstract: Described herein are systems for analysis of biopolymers and complexes containing biopolymers based on optical measurement of ion flux through pores. Also described are methods of using such devices for analysis of biopolymers and complexes containing biopolymers, including methods of determining the nucleotide sequences of polynucleotides.