公开(公告)号：US20210380667A1

公开(公告)日：2021-12-09

申请号：US17284137

申请日：2019-10-08

Applicant: Novozymes A/S

Inventor： Poul Erik Pedersen ,  Esben Peter Friis ,  Carsten Andersen ,  Peter Rahbek Oestergaard ,  Johan Qvist

IPC: C07K14/81 ,  C12P21/02 ,  C12N9/99 ,  C12N9/48

Abstract: Disclosed are protease inhibitors capable of inhibiting the protease activity of a S1 or a S8 protease at ambient pH, but where the inhibitor further has a pH dependent binding to the S1 or the S8 inhibitor meaning that a complex of a S1 and a S8 protease and the inhibitor dissociates when pH is lowered to a pH below 6.0, e.g. to a pH value in the range of 4.0 to 6.0; e.g. in the range of 4.5 to 6.0; e.g. in the range of 4.5 to 5.5; whereby the protease activity is released.