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    INTRACANALICULAR INSERT COMPRISING A NON-STEROIDAL ANTI-INFLAMMATORY AGENT
    1.
    发明申请
    INTRACANALICULAR INSERT COMPRISING A NON-STEROIDAL ANTI-INFLAMMATORY AGENT 有权

    公开(公告)号：US20250064760A1

    公开(公告)日：2025-02-27

    申请号：US18726302

    申请日：2023-01-06

    Applicant: OCULAR THERAPEUTIX, INC.

    Inventor： Charles D. BLIZZARD ,  Ankita DESAI ,  Rami EL-HAYEK ,  Michael GOLDSTEIN ,  Peter JARRETT ,  Oktay UZUN

    IPC: A61K31/165 ,  A61K9/00

    Abstract: In certain embodiments, the invention relates to a sustained release biodegradable intracanalicular insert containing nepafenac dispersed in a hydrogel for the treatment of pain and inflammation. According to certain embodiments of the present invention, pain and inflammation is treated by administering a biodegradable insert into the superior and/or inferior canaliculus of the eye, wherein the insert provides sustained release of a nonsteroidal anti-inflammatory such as nepafenac that is effective for treating pain and inflammation in a patient, e.g., during a period of one or more weeks, with only a single administration, and without the need for removal of the drug-depleted insert.

    INTRACANALICULAR INSERT COMPRISING AN ANTIMICROBIAL AGENT
    4.
    发明申请
    INTRACANALICULAR INSERT COMPRISING AN ANTIMICROBIAL AGENT 有权

    公开(公告)号：US20250114373A1

    公开(公告)日：2025-04-10

    申请号：US18726303

    申请日：2023-01-06

    Applicant: OCULAR THERAPEUTIX, INC.

    Inventor： Charles D. BLIZZARD ,  Ankita DESAI ,  Michael GOLDSTEIN ,  Megan PRIEM

    IPC: A61K31/55 ,  A61K9/00

    Abstract: In certain embodiments, the invention relates to a sustained release biodegradable intracanalicular insert containing besifloxacin dispersed in a hydrogel for the treatment of eye infection. According to certain embodiments of the present invention, eye infection is treated by administering a biodegradable insert into the superior and/or inferior canaliculus of the eye, wherein the insert provides sustained release of an antibiotic such as besifloxacin that is effective for treating eye infection in a patient, e.g., during a period of one or more weeks, with only a single administration, and without the need for removal of the drug-depleted insert.

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