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1.
公开(公告)号:US20190110687A1
公开(公告)日:2019-04-18
申请号:US16085210
申请日:2017-03-16
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor: James COE , Heather ALLEN , Charles HITCHCOCK , Edward W. MARTIN
Abstract: Disclosed are systems and methods utilizing an infrared probe and discriminating software to rapidly discriminate normal tissue processes from normal tissue during surgery, physical examination of in-situ lesions, and in the assessment of biopsy and resected tissue specimens. Examples demonstrate discrimination of cancerous from noncancerous tissues. The discriminating software, i.e. the metrics, algorithms, calibrant spectra, and decision equations, allows tissue to be identified as abnormal or normal using a minimum of infrared (IR) wavelengths in order to be measured rapidly. The probe records IR metrics approximately 1000 times faster than current commercial instruments, i.e. on a timescale fast enough for clinical use. The probe uses a tunable mid-infrared laser with a small set of selected wavelengths that are optimized for detecting the chemical and molecular signatures of tissue specific lesions to include, but not limited to, cancer, preneoplasia, intracellular accumulations (e.g. steatosis), inflammation, and wound healing.
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公开(公告)号:US20250017470A1
公开(公告)日:2025-01-16
申请号:US18639245
申请日:2024-04-18
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor: James COE , Heather ALLEN , Charles HITCHCOCK , Edward W. MARTIN
IPC: A61B5/00 , A61B17/00 , A61B90/00 , G01J3/42 , G01N21/3563 , G01N21/552
Abstract: Disclosed are systems and methods utilizing an infrared probe and discriminating software to rapidly discriminate abnormal tissue processes from normal tissue during surgery, physical examination of in-situ lesions, and in the assessment of biopsy and resected tissue specimens. Examples demonstrate discrimination of cancerous from noncancerous tissues. The discriminating software, i.e. the metrics, algorithms, calibrant spectra, and decision equations, allows tissue to be identified as abnormal or normal using a minimum of infrared (IR) wavelengths in order to be measured rapidly. The probe records IR metrics approximately 1000 times faster than current commercial instruments, i.e. on a timescale fast enough for clinical use. The probe uses a tunable mid-infrared laser with a small set of selected wavelengths that are optimized for detecting the chemical and molecular signatures of tissue specific lesions to include, but not limited to, cancer, preneoplasia, intracellular accumulations (e.g. steatosis), inflammation, and wound healing.
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3.
公开(公告)号:US20230346223A1
公开(公告)日:2023-11-02
申请号:US18139722
申请日:2023-04-26
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor: James COE , Heather ALLEN , Charles HITCHCOCK , Edward W. MARTIN
IPC: A61B5/00 , G01N21/552 , G01N21/3563 , G01J3/42
CPC classification number: A61B5/0075 , G01N21/552 , G01N21/3563 , A61B5/444 , G01J3/42 , A61B2090/373
Abstract: Disclosed are systems and methods utilizing an infrared probe and discriminating software to rapidly discriminate abnormal tissue processes from normal tissue during surgery, physical examination of in-situ lesions, and in the assessment of biopsy and resected tissue specimens. Examples demonstrate discrimination of cancerous from noncancerous tissues. The discriminating software, i.e. the metrics, algorithms, calibrant spectra, and decision equations, allows tissue to be identified as abnormal or normal using a minimum of infrared (IR) wavelengths in order to be measured rapidly. The probe records IR metrics approximately 1000 times faster than current commercial instruments, i.e. on a timescale fast enough for clinical use. The probe uses a tunable mid-infrared laser with a small set of selected wavelengths that are optimized for detecting the chemical and molecular signatures of tissue specific lesions to include, but not limited to, cancer, preneoplasia, intracellular accumulations (e.g. steatosis), inflammation, and wound healing.
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