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公开(公告)号：US20150362715A1
公开(公告)日：2015-12-17
申请号：US14722519
申请日：2015-05-27
Applicant: OLYMPUS CORPORATION
Inventor： Hirokazu KUBO
CPC classification number: G02B21/361 , G01N21/6456 , G01N21/6458 , G02B21/06 , G02B21/16
Abstract: By using a PPD as a detector, photon count loss is reduced to the utmost, and the incident light-intensity range in which light can be detected is widened. Provided is a laser microscope apparatus including an objective lens that collects return light from a specimen; a collimator lens that converts the return light collected by the objective lens into a substantially collimated beam, a PPD including a plurality of pixels that detect the return light converted to a substantially collimated beam by the collimator lens; and a controller that makes the beam diameter of the return light incident on the PPD substantially equal to an effective detection area of the PPD, formed by the plurality of pixels.
Abstract translation: 通过使用PPD作为检测器，光子计数损失被最大限度地减少，并且能够检测光的入射光强度范围变宽。 提供了一种包括从样本收集返回光的物镜的激光显微镜装置; 准直透镜，其将由物镜收集的返回光转换成基本上准直的光束; PPD，包括多个像素，其检测由准直透镜转换为基本上准直的光束的返回光; 以及控制器，其使得入射到PPD上的返回光的光束直径基本上等于由多个像素形成的PPD的有效检测区域。
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公开(公告)号：US20170336611A1
公开(公告)日：2017-11-23
申请号：US15494658
申请日：2017-04-24
Applicant: OLYMPUS CORPORATION
Inventor： Hirokazu KUBO
CPC classification number: G02B21/02 , G01N21/6458 , G01N2021/6478 , G01N2201/06113 , G02B21/0044 , G02B21/0048 , G02B21/04 , G02B21/06 , G02B21/16
Abstract: A microscope apparatus provided with: a disk unit obtained by integrally forming a pinhole array disk in which pinholes are arranged and a microlens array disk in which microlenses are arranged; a dichroic mirror focusing illumination light that has been transmitted through the microlenses of the disk unit, on the corresponding pinholes and splitting off fluorescence from a specimen that has passed through the pinholes in the reverse direction from the illumination light; an objective lens radiating the illumination light that has passed through the pinholes onto the specimen and focusing the fluorescence from the specimen on the pinholes; an illumination-light-axis adjustment mechanism adjusting the position and the angle of the optical axis of the illumination light; an installation-angle adjustment mechanism adjusting the installation angle of the disk unit; and a unit insertion/removal mechanism removably supporting the disk unit onto the optical axis of the illumination light.
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3.发明申请公开(公告)号：US20180188518A1
公开(公告)日：2018-07-05
申请号：US15906053
申请日：2018-02-27
Applicant: OLYMPUS CORPORATION
Inventor： Hirokazu KUBO
CPC classification number: G02B21/361 , G01N21/6456 , G01N21/6458 , G02B21/06 , G02B21/16
Abstract: A laser microscope apparatus including a light source that generates a laser light serving as excitation light; a mirror scanner that scans the laser light onto a specimen; an objective lens that radiates the laser light onto the specimen and that collects light from the specimen; a uniform-illumination element that causes the light from the specimen collected by the objective lens to have a substantially uniform intensity distribution; and a photodetector that detects the light uniformized by the uniform-illumination element in a Geiger mode and that has a detector including a plurality of detection elements, the detector outputting a sum of outputs from the plurality of detection elements as an intensity signal.
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公开(公告)号：US20160231547A1
公开(公告)日：2016-08-11
申请号：US15008249
申请日：2016-01-27
Applicant: OLYMPUS CORPORATION
Inventor： Hirokazu KUBO
CPC classification number: G02B21/008 , G02B21/0064 , G02B21/361
Abstract: A laser microscope apparatus including: a scanning unit that scans laser light on a sample; an objective lens that collects observation light from the sample; a photo-detection unit that has a light-receiving surface formed of an array of a plurality of detecting elements capable of detecting a single photon, that receives the observation light incident on the light-receiving surface, and that outputs intensity signals having intensities corresponding to the amounts of the received observation light; an image generating unit that generates an image on the basis of the intensities of the intensity signals and scanning positions of the laser light; a processor for notifying a user when the intensity signals used to generate the image include intensity signals having intensities equal to or larger than a predetermined threshold that is set according to the beam diameter of the observation light incident on the light-receiving surface.
Abstract translation: 一种激光显微镜装置，包括：扫描单元，其对样品上的激光进行扫描; 从样品收集观察光的物镜; 光检测单元，其具有由能够检测单个光子的多个检测元件的阵列形成的受光面，其接收入射在受光面上的观察光，并输出具有相应强度的强度信号 对所接收的观察光量; 图像生成单元，其基于强度信号的强度和激光的扫描位置生成图像; 用于当用于生成图像的强度信号时通知用户的处理器包括强度等于或大于根据入射在受光面上的观察光束的光束直径而设定的预定阈值的强度信号。
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Patent Agency Ranking
公开(公告)号：US20130083816A1
公开(公告)日：2013-04-04
申请号：US13625228
申请日：2012-09-24
Applicant: Olympus Corporation
Inventor： Hirokazu KUBO
IPC: H01S3/10
CPC classification number: H01S3/0057 , G02B21/0032 , G02B21/0076 , G02B2207/114 , G02F1/3532 , G02F1/39 , H01S3/0092
Abstract: Provided is a laser source apparatus including a single laser source that emits an ultrashort-pulse laser beam; a wavelength conversion mechanism that generates a plurality of pulsed laser beams having different wavelengths by converting at least a part of wavelength of the ultrashort-pulse laser beam; a dispersion adjusting section that adjusts the amount of frequency dispersion for each of the pulsed laser beams; and an introducing optics that emits the plurality of pulsed laser beams whose frequency dispersion amounts are adjusted by the dispersion adjusting section. The dispersion adjusting section adjusts the amount of frequency dispersion for each of the pulsed laser beams so that each of the pulsed laser beams introduced to the irradiation optics of the optical apparatus from the introducing optics to excite a specimen is close to a substantially Fourier-transform-limited pulse.
Abstract translation: 提供了一种激光源装置，其包括发射超短脉冲激光束的单个激光源; 波长转换机构，其通过转换所述超短脉冲激光束的至少一部分波长来生成具有不同波长的多个脉冲激光束; 调整每个脉冲激光束的频率分散量的色散调节部分; 以及引入光学器件，其发射由色散调节部分调节其频率分散量的多个脉冲激光束。 色散调整部分调节每个脉冲激光束的频率色散量，使得从引入光学器件引入光学装置的照射光学元件的每个脉冲激光束激发样本都接近基本上是傅里叶变换 无限脉冲
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公开(公告)号：US20220335582A1
公开(公告)日：2022-10-20
申请号：US17857562
申请日：2022-07-05
Applicant: OLYMPUS CORPORATION
Inventor： Kanako ISONO , Hirokazu KUBO
Abstract: The image processing system includes a scanner, a pixelated photon detector (PPD), and at least one processor. The at least one processor displays a setting screen on a display unit. The setting screen is a screen for setting an identification range that is a range of gradation to be identified. The at least one processor displays a second image obtained by converting a first image on the display unit. The second image is an image obtained by converting the first image based on at least the identification range. The first image is generated based on an intensity signal of light detected by a PPD and a scanning position by the scanner.
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公开(公告)号：US20180284413A1
公开(公告)日：2018-10-04
申请号：US15937684
申请日：2018-03-27
Applicant: OLYMPUS CORPORATION , NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY , OSAKA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
Inventor： Hirokazu KUBO , Shigehito MIKI , Hirotaka TERAI , Taro YAMASHITA , Tokuko HARAGUCHI , Yasushi HIRAOKA , Masataka KINJO
CPC classification number: G02B21/18 , G01N21/6458 , G01N2201/0231 , G01N2201/06113 , G02B21/0048 , G02B21/0076 , G02B21/008 , G02B21/28
Abstract: Provided is a light detecting device including: a light path branching unit that branches a single detection light path of fluorescence from a specimen, into a plurality of branched light paths; a plurality of light detectors that are provided to the respective branched light paths branched by the light path branching unit and that include an SSPD or Geiger mode APD to detect the fluorescence; and a signal adder that generates a single image signal in accordance with the detection signals outputted from the plurality of light detectors.
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公开(公告)号：US20180113291A1
公开(公告)日：2018-04-26
申请号：US15729016
申请日：2017-10-10
Applicant: OLYMPUS CORPORATION
Inventor： Hirokazu KUBO
IPC: G02B21/00 , G01J1/44 , H01L31/09 , H01L31/024 , H01L31/0352
CPC classification number: G02B21/0064 , G01J1/44 , G01J2001/442 , G02B21/0048 , G02B21/0076 , G02B21/008 , G02B27/141 , H01L31/024 , H01L31/035227 , H01L31/09 , H01L39/14
Abstract: Provided is a laser microscope that includes a beam-scanning unit that scans a sample with a laser beam emitted from a laser light source; two or more photodetectors each formed of a superconducting nanowire single photon detector that detects a beam returning from the sample as a result of the scanning of the laser beam by the beam-scanning unit; and one cryocooler that cools the photodetectors. The photodetectors respectively detect beams that have passed through different channels.
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公开(公告)号：US20170153433A1
公开(公告)日：2017-06-01
申请号：US15352734
申请日：2016-11-16
Applicant: OLYMPUS CORPORATION
Inventor： Hirokazu KUBO
CPC classification number: G02B21/0044 , G02B21/0032 , G02B21/006 , G02B27/0068 , G02B27/48
Abstract: A confocal scanner into which light from a light source is introduced via a multimode optical fiber includes: a disk unit that includes a rotary disk; and an optical system that irradiates the rotary disk with light from an emission end face of the optical fiber. The optical system includes an element that changes a size in which the emission end face of the optical fiber is projected onto the rotary disk.
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