公开(公告)号：US20160305889A1

公开(公告)日：2016-10-20

申请号：US15030183

申请日：2014-10-20

Applicant: OSAKA UNIVERSITY

Inventor： Hiroyuki YOSHIKAWA ,  Eiichi TAMIYA ,  Shuhei IMURA

IPC: G01N21/82 ,  G01N21/78 ,  C12Q1/26

CPC classification number: G01N21/82 ,  C12Q1/26 ,  G01N21/78 ,  G01N33/535 ,  G01N33/581 ,  G01N2021/7773 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2333/904

Abstract: The present invention provide a method for detecting a test substance utilizing a color development caused by an enzyme reaction, or a color development caused by a specific interaction such as an antigen-antibody reaction and an enzyme reaction, the test substance being detected rapidly, sensitively and quantitatively without using a spectroscopic measurement device. The method for measuring a concentration of a test substance by the present invention comprises the steps of: generating a peroxide from the test substance; obtaining a polymerized substance by bringing an oxidoreductase for producing a polymerized substance and a substrate of the oxidoreductase for producing a polymerized substance into contact with the peroxide; and irradiating the polymerized substance with light to record a temporal variation information of an intensity of scattered light generated from an irradiation point.

Abstract translation: 本发明提供一种利用酶反应引起的显色或由抗原 - 抗体反应和酶反应等特定相互作用引起的显色检测检测物质的方法，检测物质被快速检测 并且定量地不使用光谱测量装置。 通过本发明测定被检物质的浓度的方法包括以下步骤：从测试物质产生过氧化物; 通过使生成聚合物质的氧化还原酶和用于制备聚合物质的氧化还原酶的底物与过氧化物接触来获得聚合物质; 并用光照射聚合物，记录从照射点产生的散射光的强度的时间变化信息。

公开(公告)号：US20170189873A1

公开(公告)日：2017-07-06

申请号：US15308645

申请日：2015-05-08

Applicant: OSAKA UNIVERSITY

Inventor： Masato SAITO ,  Yuichiro KIRIYAMA ,  Eiichi TAMIYA

IPC: B01J4/02 ,  G01N37/00 ,  G01N21/07 ,  C12M1/00

CPC classification number: B01J4/02 ,  B01L3/50273 ,  B01L7/525 ,  B01L2200/0605 ,  B01L2200/142 ,  B01L2300/0803 ,  B01L2300/0867 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/1805 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0445 ,  C12M1/00 ,  G01N21/07 ,  G01N37/00

Abstract: A thermal convection generating chip (1) includes a rotatory body (2), a thermal convection pathway (11) provided in the rotatory body (2), and a supply path (12A to 12C) that supplies a liquid to the thermal convection pathway (11). The supply path (12A to 12C) includes a liquid receiving section (121) that receives the liquid and a suction passage (122) that provides communication between the liquid receiving section (121) and the thermal convection pathway (11). The suction passage (122) has a first region (122a) extending between a midsection of the suction passage (122) and the thermal convection pathway (11), and a second region (122b) extending between the midsection and the liquid receiving section (121). The liquid in the first region (122a) is separated from the liquid in the second region (122b) through rotation of the rotatory body (2) to be supplied to the thermal convection pathway (11).

公开(公告)号：US20160325282A1

公开(公告)日：2016-11-10

申请号：US15108154

申请日：2014-12-26

Applicant: KYOCERA CORPORATION ,  OSAKA UNIVERSITY

Inventor： Hideharu KURIOKA ,  Hiroyasu TANAKA ,  Masato SAITO ,  Eiichi TAMIYA

IPC: B01L3/00 ,  G01N29/22 ,  G01N33/49 ,  G01N29/02

CPC classification number: B01L3/502753 ,  B01L2200/027 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N33/49 ,  G01N33/491 ,  G01N2291/02466 ,  G01N2291/0423

Abstract: A liquid specimen sensor has a filter filtering a liquid specimen, a first channel which is located downstream relative to the filter and is formed from a capillary, a second channel which is located downstream relative to the filter and is formed from a capillary, and a sensor element which is located in the second channel and outputs a signal in accordance with an ingredient of the liquid specimen.

Abstract translation: 液体样本传感器具有对液体样本进行过滤的过滤器，位于下游的第一通道，其相对于过滤器并且由毛细管形成，第二通道相对于过滤器位于下游并由毛细管形成， 传感器元件，其位于第二通道中，并且根据液体样本的成分输出信号。

公开(公告)号：US20160169874A1

公开(公告)日：2016-06-16

申请号：US15050220

申请日：2016-02-22

Applicant: KYOCERA CORPORATION ,  OSAKA UNIVERSITY

Inventor： Hiroyasu TANAKA ,  Hideharu KURIOKA ,  Eiichi TAMIYA ,  Masato SAITO

IPC: G01N33/53

CPC classification number: G01N33/5304 ,  G01N29/022 ,  G01N33/5308

Abstract: A sensor is provided with a sensor element which outputs a signal in accordance with a detected object contained in a specimen positioned on a detection part in an element surface and with a package which accommodates the sensor element inside it and has a passage including a space positioned on the element surface. A lower surface of the passage has the element surface and a lower surface of an inflow passage extending toward the space, and a gap is positioned between the lower surface of the inflow passage and the element surface. The element surface is positioned above the lower surface of the inflow passage.

Abstract translation: 传感器设置有传感器元件，该传感器元件根据包含在位于元件表面中的检测部分上的样本中的检测对象输出信号，并且具有将传感器元件容纳在其内的包装，并具有包括位置的空间的通道 在元素表面。 通道的下表面具有元件表面和朝向空间延伸的流入通道的下表面，并且间隙位于流入通道的下表面和元件表面之间。 元件表面位于流入通道的下表面之上。

公开(公告)号：US20160214112A1

公开(公告)日：2016-07-28

申请号：US15021087

申请日：2014-03-07

Applicant: OSAKA UNIVERSITY

Inventor： Masato SAITO ,  Eiichi TAMIYA

IPC: B01L7/00 ,  C12Q1/68 ,  C12P19/34

CPC classification number: B01L7/525 ,  B01L3/50273 ,  B01L2200/06 ,  B01L2200/0684 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/088 ,  B01L2300/1805 ,  B01L2400/0409 ,  B01L2400/0445 ,  B01L2400/0688 ,  C12P19/34 ,  C12Q1/686

Abstract: A thermal convection generating device (1) that generates thermal convection of a liquid by heating or cooling the liquid and applying centrifugal force to the liquid, the thermal convection generating device including: a stage (20) to which a thermal convection generating chip (10) is attachable and detachable, the thermal convection generating chip including a disk-like substrate (11) and a thermal convection pathway (14) formed in a surface of the disk-like substrate that is perpendicular to an axis (AX) of the disk-like substrate, and being configured to rotate about the axis of the disk-like substrate to apply centrifugal force to a liquid in the thermal convection pathway; a heat controller (30) that heats or cools a portion of the thermal convection pathway; a motor (40) that drives the thermal convection generating chip to rotate about the axis; and a controller (50) that controls the heat controller and the motor.

Abstract translation: 一种通过加热或冷却液体并对液体施加离心力来产生液体的热对流的热对流产生装置（1），所述热对流产生装置包括：阶段（20），热对流产生芯片（10） ）是可附接和可拆卸的，热对流产生芯片包括形成在盘状基板的与盘的轴线（AX）垂直的表面中的盘状基板（11）和热对流通路（14） 并且被配置为围绕所述盘状基底的轴线旋转以对所述热对流路径中的液体施加离心力; 加热或冷却热对流路径的一部分的热控制器（30）; 驱动所述热对流产生芯片绕所述轴线旋转的马达（40）; 以及控制器（50），其控制所述热控制器和所述电动机。