公开(公告)号：US20160324960A1

公开(公告)日：2016-11-10

申请号：US15223566

申请日：2016-07-29

Applicant: DAIICHI SANKYO COMPANY, LIMITED ,  OSAKA UNIVERSITY

Inventor： Yukako Fujinaga ,  Takuhiro Matsumura ,  Masahiro Yutani ,  Nao Jonai

IPC: A61K39/39 ,  A61K39/145 ,  C12N7/00 ,  C07K14/33

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/575 ,  C07K14/33 ,  C07K14/77 ,  C07K2319/42 ,  C12N7/00 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/39 ,  Y02A50/466 ,  Y02A50/472

Abstract: An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response on the mucosa. According to the present invention, an adjuvant for a mucosal vaccine comprising a protein complex composed of hemagglutinin (HA) subcomponents HA1, HA2, and HA3 of botulinum toxin is provided.

公开(公告)号：US20170196970A1

公开(公告)日：2017-07-13

申请号：US15315015

申请日：2015-06-02

Applicant: OSAKA UNIVERSITY

Inventor： Nao Jonai ,  Yukako Fujinaga ,  Masahiro Yutani ,  Yo Sugawara ,  Takuhiro Matsumura

IPC: A61K39/39 ,  A61K39/145

CPC classification number: A61K39/39 ,  A61K39/02 ,  A61K39/04 ,  A61K39/08 ,  A61K39/09 ,  A61K39/095 ,  A61K39/102 ,  A61K39/12 ,  A61K39/125 ,  A61K39/13 ,  A61K39/145 ,  A61K39/15 ,  A61K39/155 ,  A61K39/165 ,  A61K39/20 ,  A61K39/21 ,  A61K39/215 ,  A61K39/235 ,  A61K39/245 ,  A61K39/25 ,  A61K39/29 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55516 ,  Y02A50/386 ,  Y02A50/39 ,  Y02A50/466 ,  Y02A50/472

Abstract: An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response in a mucosal membrane. According to the present invention, an adjuvant for a mucosal vaccine containing a protein complex composed of hemagglutinin (HA) subcomponents HA1 and HA2, and mutant subcomponent HA3 of botulinum toxin is provided.

公开(公告)号：US10226529B2

公开(公告)日：2019-03-12

申请号：US15315015

申请日：2015-06-02

Applicant: OSAKA UNIVERSITY

Inventor： Nao Jonai ,  Yukako Fujinaga ,  Masahiro Yutani ,  Yo Sugawara ,  Takuhiro Matsumura

IPC: A61K39/00 ,  A61K39/02 ,  A61K39/08 ,  A61K39/09 ,  A61K39/04 ,  A61K39/39 ,  A61K39/095 ,  A61K39/102 ,  A61K39/12 ,  A61K39/125 ,  A61K39/13 ,  A61K39/145 ,  A61K39/15 ,  A61K39/155 ,  A61K39/165 ,  A61K39/20 ,  A61K39/21 ,  A61K39/215 ,  A61K39/235 ,  A61K39/245 ,  A61K39/25 ,  A61K39/29

Abstract: An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response in a mucosal membrane. According to the present invention, an adjuvant for a mucosal vaccine containing a protein complex composed of hemagglutinin (HA) subcomponents HA1 and HA2, and mutant subcomponent HA3 of botulinum toxin is provided.

公开(公告)号：US09662386B2

公开(公告)日：2017-05-30

申请号：US15223566

申请日：2016-07-29

Applicant: OSAKA UNIVERSITY

Inventor： Yukako Fujinaga ,  Takuhiro Matsumura ,  Masahiro Yutani ,  Nao Jonai

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K39/02 ,  C07K14/33 ,  A61K39/145 ,  C07K14/77 ,  C12N7/00

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/575 ,  C07K14/33 ,  C07K14/77 ,  C07K2319/42 ,  C12N7/00 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/39 ,  Y02A50/466 ,  Y02A50/472

Abstract: An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response on the mucosa. According to the present invention, an adjuvant for a mucosal vaccine comprising a protein complex composed of hemagglutinin (HA) subcomponents HA1, HA2, and HA3 of botulinum toxin is provided.

公开(公告)号：US20150306214A1

公开(公告)日：2015-10-29

申请号：US14649279

申请日：2013-11-15

Applicant: DAIICHI SANKYO COMPANY LIMITED ,  OSAKA UNIVERSITY

Inventor： Yukako Fujinaga ,  Takuhiro Matsumura ,  Masahiro Yutani ,  Nao Jonai

IPC: A61K39/39 ,  A61K39/145

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/575 ,  C07K14/33 ,  C07K14/77 ,  C07K2319/42 ,  C12N7/00 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/39 ,  Y02A50/466

Abstract: An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response on the mucosa. According to the present invention, an adjuvant for a mucosal vaccine comprising a protein complex composed of hemagglutinin (HA) subcomponents HA1, HA2, and HA3 of botulinum toxin is provided.

Abstract translation: 本发明的一个目的是提供一种具有高安全性的粘膜疫苗佐剂，其诱导对粘膜的足够的免疫应答。 根据本发明，提供了一种粘膜疫苗佐剂，其包含由肉毒杆菌毒素的血凝素（HA），副成分HA1，HA2和HA3组成的蛋白质复合物。