公开(公告)号：US20240344134A1

公开(公告)日：2024-10-17

申请号：US18292652

申请日：2022-07-26

Applicant: OSAKA UNIVERSITY

Inventor： Hayato HIKITA ,  Yuta MYOJIN ,  Tetsuo TAKEHARA

IPC: C12Q1/6886 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  G01N33/57438 ,  C12Q2600/158

Abstract: The method of the present invention for evaluating the risk of developing liver cancer in a subject includes (1) a step of measuring a GDF15 level of a subject and (2) a step of relating the GDF15 level to the risk of developing liver cancer. When the GDF15 level measured in step (1) is not less than a cutoff value set in advance, the GDF15 level becomes an indicator that the subject has a high risk of developing liver cancer, and when the GDF15 level is less than the cutoff value, it becomes an indicator that the risk of developing liver cancer is low. The present invention also provides a kit for measuring GDF15 levels in a subject for use in the method of the present invention, and a diagnostic agent for evaluating the risk of developing liver cancer in a subject, which contains an anti-GDF15-specific antibody.

公开(公告)号：US20240285599A1

公开(公告)日：2024-08-29

申请号：US18577263

申请日：2022-08-02

Applicant: OSAKA UNIVERSITY

Inventor： Takahiro KODAMA ,  Yuto SHIODE ,  Tetsuo TAKEHARA

IPC: A61K31/4439 ,  A61P35/00 ,  G01N33/50

CPC classification number: A61K31/4439 ,  A61P35/00 ,  G01N33/5011 ,  G01N2333/912

Abstract: It is an object to provide a composition that suppresses the transdifferentiation of a mature hepatocyte or a composition that can treat cholangiocarcinoma, and it is another object to provide a method of screening a substance for the suppression of the transdifferentiation of a mature hepatocyte or a substance for the treatment of cholangiocarcinoma. Provided is a composition that suppresses the transdifferentiation of a mature hepatocyte or a composition for the treatment of cholangiocarcinoma, the composition including an NF-κB inducing kinase inhibitor (NIK inhibitor). Also provided is a method of screening a substance that suppresses the transdifferentiation of a mature hepatocyte or a substance that treats cholangiocarcinoma, the method including a step of measuring the activity of an NF-κB inducing kinase. The composition of the present invention alleviates the dysregulation of a TRAF3-NIK axis involved in the transdifferentiation of a mature hepatocyte, and the development and exacerbation of cholangiocarcinoma.