公开(公告)号：US20210046122A1

公开(公告)日：2021-02-18

申请号：US16961354

申请日：2019-01-11

Applicant: OSAKA UNIVERSITY ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kohji NISHIDA ,  Ryuhei HAYASHI ,  Shun SHIBATA ,  Toru OKUBO ,  Yoichi HONMA

IPC: A61K35/28 ,  A61P27/02

Abstract: The present invention addresses the problem of providing a novel therapeutic agent that is effective against diseases involving stratified squamous epithelial cells such as dry eye syndrome. The present invention is an agent for promoting normal differentiation/maturation of stratified squamous epithelial cells, which comprises a secretion of mesenchymal stem cells. It is preferable that the secretions not include animal serum, that the mesenchymal stem cells be adipose-derived mesenchymal stem cells, umbilical cord-derived mesenchymal stem cells, or bone marrow-derived mesenchymal stem cells, and that the stratified squamous epithelial cells be at least one selected from the group consisting of corneal epithelial cells, conjunctival epithelial cells, epidermal keratinocytes, oral epithelial cells, epiglottic epithelial cells, esophageal epithelial cells, vaginal epithelial cells, vocal fold epithelial cells, nasal epithelial cells, and nasal vestibular epithelial cells.

公开(公告)号：US20190015452A1

公开(公告)日：2019-01-17

申请号：US15749766

申请日：2016-08-03

Applicant: OSAKA UNIVERSITY ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kohji NISHIDA ,  Ryuuhei HAYASHI ,  Yoichi HONMA ,  Toru OKUBO ,  Shun SHIBATA

IPC: A61K35/28 ,  A61P27/02 ,  C12N5/0775 ,  C12N5/00

Abstract: The present invention relates to mesenchymal stem cell-derived microparticles having activity that promotes the growth of corneal epithelial stem cells and/or corneal epithelial cells, activity that maintains corneal epithelial stem cells in an undifferentiated state or promotes the formation of colonies thereby, and function that protects corneal epithelium.

公开(公告)号：US20210263339A1

公开(公告)日：2021-08-26

申请号：US17254120

申请日：2019-06-20

Applicant: OSAKA UNIVERSITY

Inventor： Kohji NISHIDA ,  Koichi BABA ,  Shizuka KOH ,  Kei OHKUBO ,  Haruyasu ASAHARA ,  Tsuyoshi INOUE ,  Hiroshi UYAMA ,  Taka-Aki ASOH

IPC: G02C7/04 ,  A61F2/16 ,  B29D11/00

Abstract: The present invention provides a new method for producing a lens to be fitted to an eye in a simple manner at a low cost. In order to achieve the aforementioned object, the present invention provides a method for producing a lens to be fitted to an eye, including the step of: hydrophilizing a surface of a polymer lens by reacting with a compound radical, wherein the compound radical is a radical containing one element selected from the group consisting of Group 15 elements and Group 16 elements, and a Group 17 element.

公开(公告)号：US20210038077A1

公开(公告)日：2021-02-11

申请号：US16964029

申请日：2019-01-25

Applicant: OSAKA UNIVERSITY

Inventor： Kohji NISHIDA ,  Kazuichi MARUYAMA ,  Noriyasu HASHIDA ,  Reiko KOBAYASHI

IPC: A61B3/14 ,  A61B3/10 ,  A61B5/16

Abstract: A method for detecting a stressed state, including a step of detecting a stressed state of a subject based on a tomographic image of a choroid of the subject, and a stress detection apparatus including: an image acquisition unit that acquires a tomographic image of a choroid of a subject; a calculation unit that calculates a choroidal thickness or a volume of the choroid based on the tomographic image; and a detection unit that detects a stressed state of the subject based on the choroidal thickness or the volume of the choroid.

公开(公告)号：US20240274295A1

公开(公告)日：2024-08-15

申请号：US18566168

申请日：2022-05-31

Applicant: OSAKA UNIVERSITY

Inventor： Yoko FUKUSHIMA ,  Kohji NISHIDA ,  Ryosuke KOJIMA ,  Yasushi OKUNO

IPC: G16H50/30 ,  G16H20/00

CPC classification number: G16H50/30 ,  G16H20/00

Abstract: There are provided a highly versatile method for screening for retinopathy of prematurity, a screening apparatus, and a trained model that are capable of accurately predict the progression of retinopathy of prematurity at appropriate timing. There is provided a method for screening for retinopathy of prematurity to predict the progression of retinopathy of prematurity, the method including a treatment determination step of determining whether or not treatment is indicated for retinopathy of prematurity after a predetermined number of days after birth based on premature infant information including postnatal time-series data on weight, height, and vital signs of a premature infant whose gestational age is less than a predetermined week.

公开(公告)号：US20190099076A1

公开(公告)日：2019-04-04

申请号：US16085595

申请日：2017-02-20

Applicant: OSAKA UNIVERSITY ,  TOPCON CORPORATION

Inventor： Takashi FUJIKADO ,  Masakazu HIROTA ,  Kohji NISHIDA ,  Makoto SAIKA ,  Tatsuo YAMAGUCHI ,  Suguru MIYAGAWA

IPC: A61B3/113 ,  A61B3/00

Abstract: An eye-fatigue examining device and an eye-fatigue examining method capable of examining eye fatigue of a subject's eye regardless of an age of a patient are provided. The eye-fatigue examining device includes: a light quantity difference adjusting unit that increases a light quantity difference between lights respectively incident on right and left subject's eyes; a gaze direction detecting unit that detects gaze directions of the respective subject's eyes while the light quantity difference adjusting unit increases the light quantity difference; and a light quantity difference deciding unit that decides a specific light quantity difference at which a change in the gaze directions due to the increase in the light quantity difference occurs, based on the detection result of the gaze direction detecting unit.

公开(公告)号：US20210290432A1

公开(公告)日：2021-09-23

申请号：US16346641

申请日：2017-11-07

Applicant: OSAKA UNIVERSITY

Inventor： Koichi BABA ,  Kohji NISHIDA

IPC: A61F9/00 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  C08L5/04 ,  G02C7/04

Abstract: Provided is an inexpensive keratoconjunctival cover sheet that is comfortable and has good oxygen-permeability, contamination-resistance, wettability, handleability, and optical properties, and that can be used for medical treatment, visual correction, a cosmetic application, and the like. The keratoconjunctival cover sheet is constituted by a gel layer that includes metal ions and a water-soluble gelling agent exhibiting a gelation ability in the presence of the metal ions, and has a surface area capable of covering a cornea or keratoconjunctiva.

公开(公告)号：US20210214775A1

公开(公告)日：2021-07-15

申请号：US17252982

申请日：2019-06-28

Applicant: OSAKA UNIVERSITY ,  OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Kohji NISHIDA ,  Noriyasu HASHIDA ,  Tetsuya IIDA ,  Shota NAKAMURA ,  Daisuke MOTOOKA ,  Kazunobu ASAO ,  Satoru ANDO

IPC: C12Q1/689 ,  C12Q1/06

Abstract: It aims to construct a technology in which the onset or progression of an aging state or a specific disease can be evaluated in an objective and highly reproducible manner, and in particular, to provide a method of detecting conjunctival diseases such as conjunctival MALT lymphoma, and to provide an aging biomarker that serves as an indicator of the aging state.
A method of detecting a conjunctival disease using an ocular surface tissue, the method comprising a step of comparing a microbial community structure of a microbiota included in an ocular surface tissue specimen sampled from a healthy person, with a microbial community structure of a microbiota included in an ocular surface tissue specimen sampled from a subject to detect an ocular surface tissue specimen which is sampled from the subject evaluated as having the conjunctival disease based on a change in the microbial community structure between the healthy person and the subject, and an aging biomarker for detecting an aging state, the aging biomarker comprising a bacterial species which belongs to at least one family selected from Corynebacteriaceae family and Propionibacteriales family in an ocular surface tissue.

公开(公告)号：US20170253855A1

公开(公告)日：2017-09-07

申请号：US15508749

申请日：2015-09-04

Applicant: OSAKA UNIVERSITY

Inventor： Kohji NISHIDA ,  Motokazu TSUJIKAWA ,  Susumu HARA ,  Satoshi KAWASAKI ,  Masahito YOSHIHARA ,  Masayoshi ITOH ,  Hideya KAWAJI ,  Hiroko OHMIYA

IPC: C12N5/079 ,  C12N15/10 ,  C12Q1/68 ,  C12N15/67 ,  A61K35/30 ,  G01N33/569

CPC classification number: C12N5/0621 ,  A61K35/30 ,  A61L27/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/10 ,  C12N15/67 ,  C12Q1/68 ,  C12Q1/686 ,  G01N33/56966 ,  G01N2333/705 ,  G01N2333/70596

Abstract: A molecular marker expressed specifically in corneal endothelial cells, and a method for producing one or more corneal endothelial cells using the marker and a method for evaluating one or more corneal endothelial cells using the marker are provided. At least one molecule selected from the group consisting of ZP4, MRGPRX3, GRIP1, GLP1R, HTR1D, and CLRN1 is used as a marker specific to corneal endothelial cells.

公开(公告)号：US20230306568A1

公开(公告)日：2023-09-28

申请号：US18012667

申请日：2021-06-22

Applicant: Osaka University ,  Topcon Corporation

Inventor： Kohji NISHIDA ,  Kazuichi MARUYAMA ,  Atsuya MIKI ,  Ryo KAWASAKI ,  Hirokazu SAKAGUCHI ,  Chikako HARA ,  Song MEI ,  Yasufumi FUKUMA ,  Zaixing MAO ,  Zhenguo WANG ,  Kinpui CHAN

IPC: G06T5/50 ,  G06T7/11 ,  G06T7/00 ,  G06T7/60 ,  G06T7/30 ,  A61B3/10 ,  A61B3/12

CPC classification number: G06T5/50 ,  A61B3/102 ,  A61B3/1225 ,  G06T7/0014 ,  G06T7/11 ,  G06T7/30 ,  G06T7/60 ,  G06T2200/04 ,  G06T2207/10101 ,  G06T2207/20036 ,  G06T2207/20212 ,  G06T2207/30041 ,  G06T2207/30096 ,  G06T2207/30101 ,  G06T2207/30242

Abstract: A medical diagnostic apparatus includes a receiver circuit that receives three-dimensional volumetric data of a subject’s eye, and a processor configured to separate portions of the three-dimensional volumetric data into separate segments, perform processing differently on each of the separate segments, and combine the separately processed segments to produce an enhanced three-dimensional volumetric data set. The processor is further configured to generate at least one diagnostic metric from the enhanced three-dimensional volumetric data set, and the processor is further configured to evaluate a pathological condition based on the at least one diagnostic metric. Related methods and computer readable media are also disclosed.