公开(公告)号：US09107903B2

公开(公告)日：2015-08-18

申请号：US14147405

申请日：2014-01-03

Applicant: PACESETTER, INC.

Inventor： Yelena Nabutovsky ,  Gene A. Bornzin ,  Annapurna Karicherla ,  Nirav Dalal ,  Prashant Dinesh ,  Richard Samade ,  John W. Poore

IPC: A61K9/14 ,  A61K33/38 ,  A61F2/02 ,  B05D1/00 ,  A61N1/375 ,  A61F2/82 ,  A61N1/05 ,  B82Y5/00 ,  B22F1/00 ,  A61L29/16 ,  A61F2/00 ,  A61F2/30 ,  A61L31/16 ,  B82Y30/00 ,  A61L29/10 ,  A61L31/08 ,  A61K9/16

CPC classification number: A61K33/38 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/30767 ,  A61F2/82 ,  A61F2002/30011 ,  A61F2002/3084 ,  A61F2310/0052 ,  A61K9/1611 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2400/12 ,  A61L2420/08 ,  A61N1/05 ,  A61N1/375 ,  A61N1/3758 ,  B05D1/00 ,  B22F1/0018 ,  B22F2303/01 ,  B82Y5/00 ,  B82Y30/00 ,  C01P2004/54

Abstract: Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.

Abstract translation: 本文公开了包括抗微生物层的可植入医疗装置。 抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。 抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

公开(公告)号：US20140120240A1

公开(公告)日：2014-05-01

申请号：US14147405

申请日：2014-01-03

Applicant: PACESETTER, INC.

Inventor： Yelena Nabutovsky ,  Gene A. Bornzin ,  Annapurna Karicherla ,  Nirav Dalal ,  Prashant Dinesh ,  Richard Samade ,  John W. Poore

IPC: A61K33/38

CPC classification number: A61K33/38 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/30767 ,  A61F2/82 ,  A61F2002/30011 ,  A61F2002/3084 ,  A61F2310/0052 ,  A61K9/1611 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2400/12 ,  A61L2420/08 ,  A61N1/05 ,  A61N1/375 ,  A61N1/3758 ,  B05D1/00 ,  B22F1/0018 ,  B22F2303/01 ,  B82Y5/00 ,  B82Y30/00 ,  C01P2004/54

Abstract: Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.

Abstract translation: 本文公开了包括抗微生物层的可植入医疗装置。 抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。 抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

公开(公告)号：US09278218B2

公开(公告)日：2016-03-08

申请号：US14630433

申请日：2015-02-24

Applicant: PACESETTER, INC.

Inventor： Edward Karst ,  Richard Samade ,  Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Didier Theret

IPC: A61N1/00 ,  A61N1/368 ,  A61N1/365 ,  A61N1/375 ,  A61N1/372 ,  A61B5/00 ,  A61B5/042 ,  A61B5/11 ,  A61B5/0452 ,  A61B5/0464

CPC classification number: A61N1/368 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/0464 ,  A61B5/1107 ,  A61B5/6869 ,  A61B5/6882 ,  A61B2560/0468 ,  A61N1/36507 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/36592 ,  A61N1/37205 ,  A61N1/3756

Abstract: A leadless intra-cardiac medical device senses cardiac activity from multiple chambers and applies cardiac stimulation to at least one cardiac chamber and/or generates a cardiac diagnostic indication. The leadless device may be implanted in a local cardiac chamber (e.g., the right ventricle) and detect near-field signals from that chamber as well as far-field signals from an adjacent chamber (e.g., the right atrium).

公开(公告)号：US20150165199A1

公开(公告)日：2015-06-18

申请号：US14630433

申请日：2015-02-24

Applicant: PACESETTER, INC.

Inventor： Edward Karst ,  Richard Samade ,  Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Didier Theret

IPC: A61N1/368 ,  A61N1/375

CPC classification number: A61N1/368 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/0464 ,  A61B5/1107 ,  A61B5/6869 ,  A61B5/6882 ,  A61B2560/0468 ,  A61N1/36507 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/36592 ,  A61N1/37205 ,  A61N1/3756

Abstract: A leadless intra-cardiac medical device senses cardiac activity from multiple chambers and applies cardiac stimulation to at least one cardiac chamber and/or generates a cardiac diagnostic indication. The leadless device may be implanted in a local cardiac chamber (e.g., the right ventricle) and detect near-field signals from that chamber as well as far-field signals from an adjacent chamber (e.g., the right atrium).

Abstract translation: 无引导心脏内心脏医疗装置感测来自多个腔室的心脏活动，并将心脏刺激应用于至少一个心室，和/或产生心脏诊断指示。 无引线装置可以植入局部心室（例如右心室）并检测来自该腔室的近场信号以及来自相邻腔室（例如，右心房）的远场信号。