公开(公告)号：US20160317747A1

公开(公告)日：2016-11-03

申请号：US15209450

申请日：2016-07-13

Applicant: Palo Alto Research Center Incorporated

Inventor： Peter Kiesel ,  Joerg Martini ,  Eugene M. Chow ,  Scott Uhland ,  Noble M. Johnson

IPC: A61M5/30 ,  G01N15/14 ,  G01B11/14

CPC classification number: A61M5/3015 ,  A61M5/2053 ,  A61M2205/3306 ,  A61M2210/04 ,  G01B11/14 ,  G01N15/00 ,  G01N15/1434 ,  G01N2015/0003 ,  G01N2015/0046 ,  G01N2015/1075 ,  G01N2015/1087 ,  G01N2015/1093

Abstract: Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

公开(公告)号：US20150065997A1

公开(公告)日：2015-03-05

申请号：US14537585

申请日：2014-11-10

Applicant: PALO ALTO RESEARCH CENTER INCORPORATED

Inventor： Scott Uhland ,  Eric Peeters ,  Hussain Fatakdawala

IPC: A61M31/00

CPC classification number: A61M31/002 ,  A61K9/0036

Abstract: Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.

Abstract translation: 提供了用于经粘膜药物递送的装置和方法。 透粘膜药物递送装置可以包括构造成用于腔内部署的壳体，例如阴道内部分入人或动物受试者; 药物分配部分，其包含至少一种药物，所述药物分配部分构造成通过正位移从所述壳体分配药物; 以及渗透性增强剂分配部分，被配置为释放或产生渗透性增强物质，以在选择的时间在脉管内部署在人或动物受试者中的同时破坏邻近所述壳体的粘膜屏障的至少一个区域。 该装置可操作以将药物从壳体分配到由渗透性增强物质破坏的粘膜屏障的区域。

公开(公告)号：US09400174B2

公开(公告)日：2016-07-26

申请号：US14246912

申请日：2014-04-07

Applicant: Palo Alto Research Center Incorporated

Inventor： Peter Kiesel ,  Joerg Martini ,  Eugene M. Chow ,  Scott Uhland ,  Noble M. Johnson

IPC: G01B11/14 ,  G01N15/14 ,  A61M5/30 ,  G01N15/10 ,  G01N15/00

CPC classification number: A61M5/3015 ,  A61M5/2053 ,  A61M2205/3306 ,  A61M2210/04 ,  G01B11/14 ,  G01N15/00 ,  G01N15/1434 ,  G01N2015/0003 ,  G01N2015/0046 ,  G01N2015/1075 ,  G01N2015/1087 ,  G01N2015/1093

Abstract: Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

Abstract translation: 公开了确定颗粒如药物颗粒的递送成功的方法。 用于监测颗粒递送到生物组织的系统包括体积，光学部件，检测器和分析器。 该体积包括颗粒可以通过其沿所需方向通过的空间。 光学部件被配置成提供测量光。 检测器被定位成响应于测量光来检测从颗粒发出的光。 随着粒子沿着检测轴移动，被检测的光被调制。 检测器被配置为响应于检测到的光而产生时变信号。 分析器被配置为接收时变信号，并且基于时变信号的特性来确定颗粒进入生物组织的递送成功。

公开(公告)号：US20150285622A1

公开(公告)日：2015-10-08

申请号：US14246912

申请日：2014-04-07

Applicant: Palo Alto Research Center Incorporated

Inventor： Peter Kiesel ,  Joerg Martini ,  Eugene M. Chow ,  Scott Uhland ,  Noble M. Johnson

IPC: G01B11/14 ,  G01N15/14 ,  A61M5/30

CPC classification number: A61M5/3015 ,  A61M5/2053 ,  A61M2205/3306 ,  A61M2210/04 ,  G01B11/14 ,  G01N15/00 ,  G01N15/1434 ,  G01N2015/0003 ,  G01N2015/0046 ,  G01N2015/1075 ,  G01N2015/1087 ,  G01N2015/1093

Abstract: Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

Abstract translation: 公开了确定颗粒如药物颗粒的递送成功的方法。 用于监测颗粒递送到生物组织的系统包括体积，光学部件，检测器和分析器。 该体积包括颗粒可以通过其沿所需方向通过的空间。 光学部件被配置成提供测量光。 检测器被定位成响应于测量光来检测从颗粒发出的光。 随着粒子沿着检测轴移动，被检测的光被调制。 检测器被配置为响应于检测到的光而产生时变信号。 分析器被配置为接收时变信号，并且基于时变信号的特性来确定颗粒进入生物组织的递送成功。

公开(公告)号：US10064995B2

公开(公告)日：2018-09-04

申请号：US15209450

申请日：2016-07-13

Applicant: Palo Alto Research Center Incorporated

Inventor： Peter Kiesel ,  Joerg Martini ,  Eugene M. Chow ,  Scott Uhland ,  Noble M. Johnson

IPC: A61M5/30 ,  G01N15/14 ,  G01B11/14 ,  G01N15/10 ,  G01N15/00 ,  A61M5/20

Abstract: Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.