公开(公告)号：US20180180622A1

公开(公告)日：2018-06-28

申请号：US15738628

申请日：2016-06-24

Applicant: PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL

Inventor： Daniel J. Meier ,  Ruben M. Sandoval, Jr. ,  Erinn Reilly

IPC: G01N33/58 ,  A61B5/00 ,  A61B5/02 ,  A61B5/145

CPC classification number: G01N33/582 ,  A61B5/0071 ,  A61B5/02028 ,  A61B5/14535 ,  A61B2560/0233

Abstract: Disclosed are methods for determining biometric indicators such as plasma volume, hematocrit and glomerular filtration rate, in mammalian subjects such as humans. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule, or wherein the static molecule is labeled with a fluorescent tag and a dynamic molecule is labeled with another fluorescent tag. One or more measurements of the intensities of the fluorescent emissions are taken subsequent to introduction of an injectate which contains the fluorescent tags, which can be taken using a probe or via a blood or plasma sample. Compositions and apparatuses for practicing the methods are also disclosed.

公开(公告)号：US10571397B2

公开(公告)日：2020-02-25

申请号：US16116248

申请日：2018-08-29

Applicant: PHARMACOPHOTONICS, INC.

Inventor： Ruben Sandoval, Jr. ,  Erinn Reilly ,  Daniel Meier

IPC: G01N21/64 ,  A61K49/00 ,  A61M5/00

Abstract: Compositions and methods for increasing fluorescent signals generated by biomarkers are described. This serves to increase the accuracy of results when the biomarkers are used for the detection and diagnosis of physiological conditions, such as organ function and plasma volume.

公开(公告)号：US20190064068A1

公开(公告)日：2019-02-28

申请号：US16116248

申请日：2018-08-29

Applicant: PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL

Inventor： Ruben Sandoval, JR. ,  Erinn Reilly ,  Daniel Meier

IPC: G01N21/64 ,  A61K49/00 ,  A61M5/00

CPC classification number: G01N21/6428 ,  A61K49/0041 ,  A61K49/0054 ,  A61M5/007 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/13

Abstract: Compositions and methods for increasing fluorescent signals generated by biomarkers are described. This serves to increase the accuracy of results when the biomarkers are used for the detection and diagnosis of physiological conditions, such as organ function and plasma volume.

公开(公告)号：US10082465B2

公开(公告)日：2018-09-25

申请号：US15031452

申请日：2014-10-24

Applicant: PHARMACOPHOTONICS, INC.

Inventor： Ruben Sandoval, Jr. ,  Erinn Reilly ,  Daniel Meier

IPC: G01N21/64 ,  A61K49/00 ,  A61M5/00

CPC classification number: G01N21/6428 ,  A61K49/0041 ,  A61K49/0054 ,  A61M5/007 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/13

Abstract: Compositions and methods for increasing fluorescent signals generated by biomarkers are described. This serves to increase the accuracy of results when the biomarkers are used for the detection and diagnosis of physiological conditions, such as organ function and plasma volume.