公开(公告)号：US20170369519A1

公开(公告)日：2017-12-28

申请号：US15488603

申请日：2017-04-17

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Young Ho RHEE ,  Mijin KIM ,  Soyeong KANG

IPC: C07H17/04 ,  C07H15/04 ,  C07H3/06 ,  C07H3/04 ,  C07D407/12 ,  C07D309/10 ,  C07D307/32 ,  C07H15/207 ,  C07C43/215

CPC classification number: C07H17/04 ,  C07C43/215 ,  C07C43/315 ,  C07C2601/14 ,  C07D307/32 ,  C07D309/10 ,  C07D407/12 ,  C07H3/04 ,  C07H3/06 ,  C07H15/04 ,  C07H15/207

Abstract: The present invention relates to a method for the stereoselective preparation of apiose derivatives from allylic alcohol compounds and allene compounds using catalytic asymmetric synthesis. The method for the stereoselective preparation of apiose derivatives of the present invention is based on the catalytic asymmetric synthesis from allylic alcohol compounds and allene compounds in the presence of a metal catalyst, so that apiose derivatives can be produced stereoselectively, with high yield, with high optical purity regardless of the types of substituents of the compounds. The method of the invention can also be used for the preparation of oligosaccharides including monosaccharides, disaccharides, and polysaccharides or various compounds including apiose derivatives because the method can minimize the production of by-products without using an activating group, unlike the conventional method for the preparation of adipose derivatives.

公开(公告)号：US20170291885A1

公开(公告)日：2017-10-12

申请号：US15473756

申请日：2017-03-30

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Jai Wook PARK ,  Jin Yong PARK ,  Yong Jin KIM ,  Yea Rang KWON ,  Han Kyu PAK ,  Young Ho RHEE

IPC: C07D333/20 ,  C07D307/52 ,  C07C319/12 ,  B01J31/22 ,  C07D317/58 ,  C07D213/40 ,  C07D311/68 ,  C07C231/10 ,  C07C253/30

CPC classification number: C07D333/20 ,  B01J31/2295 ,  B01J2231/766 ,  B01J2531/821 ,  C07C231/10 ,  C07C231/14 ,  C07C253/30 ,  C07C319/12 ,  C07C319/20 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2602/32 ,  C07D213/40 ,  C07D307/52 ,  C07D311/68 ,  C07D317/58 ,  C07C233/09 ,  C07C233/13 ,  C07C233/20 ,  C07C233/49 ,  C07C233/06 ,  C07C323/41 ,  C07C233/43 ,  C07C255/60 ,  C07C233/65 ,  C07C233/73 ,  C07C233/66 ,  C07C233/31

Abstract: Provided is a method for preparing an enamide compound, which includes reacting an organic azide compound having α-hydrogen and an anhydride by addition of a ruthenium complex catalyst in the presence of an ionic liquid, and a ruthenium complex catalyst used herein.

公开(公告)号：US20170210765A1

公开(公告)日：2017-07-27

申请号：US15327064

申请日：2015-01-10

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Jaiwook PARK ,  Jung Joon KIM ,  Wook JEONG ,  Young Ho RHEE

IPC: C07F7/08 ,  B01J35/00 ,  B01J19/12 ,  B01J31/22

CPC classification number: C07F7/083 ,  B01J19/127 ,  B01J23/462 ,  B01J31/16 ,  B01J31/2295 ,  B01J31/28 ,  B01J35/004 ,  B01J2219/0892 ,  B01J2219/1203 ,  B01J2231/40 ,  B01J2531/821 ,  C07F7/081 ,  C07F7/1804

Abstract: The present invention relates to a process for preparing alpha-silylamine compounds and, more specifically, to a one-pot process for preparing various alpha-silylamine compounds by reacting, in the presence of a metal complex catalyst and under a mild condition, an alpha-silylmethyl azide compound as a starting material with various allylborate compounds via an alpha-silylimine intermediate which has no substituent at nitrogen.