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公开(公告)号：US20210371507A1
公开(公告)日：2021-12-02
申请号：US17307968
申请日：2021-05-04
Applicant: PROTHENA BIOSCIENCES LIMITED , UNIVERSITY HEALTH NETWORK
Inventor： YUE LIU , TARLOCHAN S. NIJJAR , AVIJIT CHAKRABARTTY , JEFFREY N. HIGAKI
Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
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公开(公告)号：US20200087386A1
公开(公告)日：2020-03-19
申请号：US16584634
申请日：2019-09-26
Applicant: PROTHENA BIOSCIENCES LIMITED , UNIVERSITY HEALTH NETWORK
Inventor： YUE LIU , TARLOCHAN S. NIJJAR , AVIJIT CHAKRABARTTY , JEFFREY N. HIGAKI
Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
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公开(公告)号：US20240141025A1
公开(公告)日：2024-05-02
申请号：US18414178
申请日：2024-01-16
Applicant: NOVO NORDISK A/S , University Health Network
Inventor： YUE LIU , TARLOCHAN S. NIJJAR , AVIJIT CHAKRABARTTY , JEFFREY N. HIGAKI
CPC classification number: C07K16/18 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/92
Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
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