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公开(公告)号：US20160004060A1
公开(公告)日：2016-01-07
申请号：US14735959
申请日：2015-06-10
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Charles Addison Bouman , Ryan Douglas Muir , Shane Sullivan , Justin Allen Newman , Mark Carlsen
CPC classification number: G02B21/0084 , G02B21/0048 , G02B21/0076 , G02B26/101
Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
Abstract translation: 描述了用于在多个同时数据采集通道上实现高达kHz帧频光学成像的波束扫描光学设计。 在一个实施例中，两个快速扫描谐振反射镜将光束引导通过视场的迂回轨迹，轨迹重复时间由反射镜周期的最小公倍数给出。 将原始时域数据划分为与基于模型的图像重建（MBIR）相结合的子轨迹。3D绘图算法允许比Lissajous轨迹的重复时间高得多的有效帧速率。 因为子轨迹和全轨迹成像是分析相同数据的不同方法，同时获取具有较低分辨率的高帧率图像和高分辨率的低帧率图像。
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Patent Agency Ranking
公开(公告)号：US10409047B2
公开(公告)日：2019-09-10
申请号：US15724738
申请日：2017-10-04
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Charles Addison Bouman , Ryan Douglas Muir , Shane Sullivan , Justin Allen Newman , Mark Carlsen , Suhas Sreehari
Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
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公开(公告)号：US20180052103A1
公开(公告)日：2018-02-22
申请号：US15555588
申请日：2016-03-04
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Justin Allen Newman , Nicholas Roman Pogranichniy , Nicole Mulready Scarborough
CPC classification number: G01N21/636 , G01N23/207 , G01N33/52 , G01N33/58 , G01N33/68 , G02F1/37
Abstract: Methods for determining the 3-D structures of proteins. Such a method includes incorporating a compound into a protein crystal such that the compound enhances the activity of the protein crystal to second harmonic generation, illuminating the protein crystal with a sufficiently intense light to cause second harmonic generation by the protein crystal, and detecting a second harmonic generation response produced by the protein crystal that is suitable for protein structure determination by diffraction analysis.
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公开(公告)号：US09784960B2
公开(公告)日：2017-10-10
申请号：US14735959
申请日：2015-06-10
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Charles Addison Bouman , Ryan Douglas Muir , Shane Sullivan , Justin Allen Newman , Mark Carlsen , Suhas Sreehari
CPC classification number: G02B21/0084 , G02B21/0048 , G02B21/0076 , G02B26/101
Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
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公开(公告)号：US10113965B2
公开(公告)日：2018-10-30
申请号：US15555588
申请日：2016-03-04
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Justin Allen Newman , Nicholas Roman Pogranichniy , Nicole Mulready Scarborough
Abstract: Methods for determining the 3-D structures of proteins. Such a method includes incorporating a compound into a protein crystal such that the compound enhances the activity of the protein crystal to second harmonic generation, illuminating the protein crystal with a sufficiently intense light to cause second harmonic generation by the protein crystal, and detecting a second harmonic generation response produced by the protein crystal that is suitable for protein structure determination by diffraction analysis.
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公开(公告)号：US20180045939A1
公开(公告)日：2018-02-15
申请号：US15724738
申请日：2017-10-04
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Charles Addison Bouman , Ryan Douglas Muir , Shane Sullivan , Justin Allen Newman , Mark Carlsen , Suhas Sreehari
CPC classification number: G02B21/0084 , G02B21/0048 , G02B21/0076 , G02B26/101
Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
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