公开(公告)号：US12091693B2

公开(公告)日：2024-09-17

申请号：US17497085

申请日：2021-10-08

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K38/00 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C12N9/96

CPC classification number: C12N9/485 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/542 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0402 ,  A61K51/0497 ,  C12N9/96 ,  A61K38/00 ,  C12Y304/17021

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10406238B2

公开(公告)日：2019-09-10

申请号：US15572985

申请日：2016-05-11

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam

IPC: A61K31/35 ,  A61K38/08 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61P29/00 ,  A61P35/00 ,  G01N33/84 ,  G01N33/533

Abstract: The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.

公开(公告)号：US20190002861A1

公开(公告)日：2019-01-03

申请号：US15934974

申请日：2018-03-24

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K49/00 ,  A61K31/454 ,  C12N9/96 ,  A61K51/04 ,  A61K47/54 ,  A61K31/475 ,  A61K31/4745 ,  A61K38/00

CPC classification number: C12N9/485 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K38/00 ,  A61K47/542 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0402 ,  A61K51/0497 ,  C12N9/96 ,  C12Y304/17021

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US11155800B2

公开(公告)日：2021-10-26

申请号：US16724729

申请日：2019-12-23

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54 ,  A61K38/00

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20150023874A1

公开(公告)日：2015-01-22

申请号：US14382177

申请日：2013-02-28

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Balasubramanian Vaitilingam ,  Venkatesh Chelvam

IPC: A61K47/48 ,  A61K31/475 ,  A61K38/06 ,  A61K51/04 ,  A61K49/00

CPC classification number: A61K47/48061 ,  A61K31/475 ,  A61K38/06 ,  A61K47/545 ,  A61K47/551 ,  A61K49/0052 ,  A61K51/0459

Abstract: The invention described herein pertains to targeted drug delivery conjugates comprising folate receptor α (FR-α) selective binding ligands and methods for diagnosing, monitoring, and eliminating pathological cells that express FR-α.

Abstract translation: 本文描述的本发明涉及包含叶酸受体α（FR-α）选择性结合配体的靶向药物递送缀合物以及用于诊断，监测和消除表达FR-α的病理细胞的方法。

公开(公告)号：US20220098564A1

公开(公告)日：2022-03-31

申请号：US17497085

申请日：2021-10-08

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US09629918B2

公开(公告)日：2017-04-25

申请号：US14382177

申请日：2013-02-28

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Balasubramanian Vaitilingam ,  Venkatesh Chelvam

IPC: A61K47/48 ,  A61K31/475 ,  A61K38/06 ,  A61K49/00 ,  A61K51/04

CPC classification number: A61K47/48061 ,  A61K31/475 ,  A61K38/06 ,  A61K47/545 ,  A61K47/551 ,  A61K49/0052 ,  A61K51/0459

Abstract: The invention described herein pertains to targeted drug delivery conjugates comprising folate receptor α (FR-α) selective binding ligands and methods for diagnosing, monitoring, and eliminating pathological cells that express FR-α.

公开(公告)号：US20200283748A1

公开(公告)日：2020-09-10

申请号：US16724729

申请日：2019-12-23

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10557128B2

公开(公告)日：2020-02-11

申请号：US15934974

申请日：2018-03-24

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54 ,  A61K38/00

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US09951324B2

公开(公告)日：2018-04-24

申请号：US15018068

申请日：2016-02-08

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54

CPC classification number: C12N9/485 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K38/00 ,  A61K47/542 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0402 ,  C12N9/96 ,  C12Y304/17021

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.