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    Use of SAM68 for modulating signaling through the TNF receptor
    1.
    发明授权
    Use of SAM68 for modulating signaling through the TNF receptor 有权
    使用SAM68通过TNF受体调节信号

    公开(公告)号：US08598137B2

    公开(公告)日：2013-12-03

    申请号：US13284792

    申请日：2011-10-28

    Applicant: Parameswaran Ramakrishnan ,  David Baltimore

    Inventor： Parameswaran Ramakrishnan ,  David Baltimore

    IPC: C12N15/113 ,  A61K39/395 ,  C07H21/04

    CPC classification number: A61K31/7105 ,  C12N15/1135 ,  C12N2310/14

    Abstract: Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent signaling, for example to inhibit NF-kB signaling or apoptosis in a patient in need. In some embodiments, functional Sam68 is administered to increase TNF-dependent signaling, for example to induce apoptosis in a patient in need. In some embodiments, methods are provided determining whether the TNF-dependent or TNF-independent branch of a signaling pathway is active in a cell or cells, or for drug screening applications.

    Abstract translation: Sam68在TNF依赖性信号传导中起重要作用，包括NF-kB信号传导和凋亡的外在激活。 在一些实施方案中，施用Sam68的抑制剂以抑制TNF依赖性信号传导，例如抑制需要的患者中的NF-kB信号传导或凋亡。 在一些实施方案中，施用功能性Sam68以增加TNF依赖性信号传导，例如在需要的患者中诱导细胞凋亡。 在一些实施方案中，提供了确定信号传导途径的TNF依赖性或不依赖于TNF的分支在细胞或细胞中活性或用于药物筛选应用的方法。

    USE OF SAM68 FOR MODULATING SIGNALING THROUGH THE TNF RECEPTOR
    2.
    发明申请
    USE OF SAM68 FOR MODULATING SIGNALING THROUGH THE TNF RECEPTOR 有权
    使用SAM68通过TNF受体进行信号调节

    公开(公告)号：US20120121608A1

    公开(公告)日：2012-05-17

    申请号：US13284792

    申请日：2011-10-28

    Applicant: Parameswaran Ramakrishnan ,  David Baltimore

    Inventor： Parameswaran Ramakrishnan ,  David Baltimore

    IPC: A61K39/395 ,  A61K31/7088 ,  A61P35/00 ,  G01N33/566 ,  C12Q1/68 ,  G01N33/573 ,  C12Q1/06 ,  A61K31/713 ,  A61K31/7105

    CPC classification number: A61K31/7105 ,  C12N15/1135 ,  C12N2310/14

    Abstract: Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent signaling, for example to inhibit NF-kB signaling or apoptosis in a patient in need. In some embodiments, functional Sam68 is administered to increase TNF-dependent signaling, for example to induce apoptosis in a patient in need. In some embodiments, methods are provided determining whether the TNF-dependent or TNF-independent branch of a signaling pathway is active in a cell or cells, or for drug screening applications.

    Abstract translation: Sam68在TNF依赖性信号传导中起重要作用，包括NF-kB信号传导和凋亡的外在激活。 在一些实施方案中，施用Sam68的抑制剂以抑制TNF依赖性信号传导，例如抑制需要的患者中的NF-kB信号传导或凋亡。 在一些实施方案中，施用功能性Sam68以增加TNF依赖性信号传导，例如在需要的患者中诱导细胞凋亡。 在一些实施方案中，提供了确定信号传导途径的TNF依赖性或不依赖于TNF的分支在细胞或细胞中活性或用于药物筛选应用的方法。

    Anti-NIK antibodies and uses thereof
    3.
    发明授权
    Anti-NIK antibodies and uses thereof 有权
    抗NIK抗体及其用途

    公开(公告)号：US08383781B2

    公开(公告)日：2013-02-26

    申请号：US10573138

    申请日：2004-10-05

    Applicant: David Wallach ,  Parameswaran Ramakrishnan

    Inventor： David Wallach ,  Parameswaran Ramakrishnan

    IPC: C07K16/40 ,  C07K16/46 ,  A61K39/395 ,  C12N5/20

    CPC classification number: C12N9/1205 ,  C07K16/40

    Abstract: An antibody or antibody preparation being capable of specifically binding the amino acid sequence of NF-&kgr; B-inducing kinase (NIK) MAP3K14, or a specific portion thereof, and of thereby regulating a biochemical activity of NIK, and/or enabling detection of NIK or a specific portion thereof.

    Abstract translation: 能够特异性结合NF-和kgr的氨基酸序列的抗体或抗体制剂; B-诱导激酶（NIK）MAP3K14或其特定部分，从而调节NIK的生化活性，和/或能够检测NIK或其特定部分。

    Remote web-based document creation system and method
    7.
    发明授权
    Remote web-based document creation system and method 有权
    远程基于Web的文档创建系统和方法

    公开(公告)号：US08086951B2

    公开(公告)日：2011-12-27

    申请号：US12256178

    申请日：2008-10-22

    Applicant: Kevin Kopp ,  Parameswaran Ramakrishnan ,  Chris Bordeman

    Inventor： Kevin Kopp ,  Parameswaran Ramakrishnan ,  Chris Bordeman

    IPC: G06F7/06 ,  G06F7/22

    CPC classification number: G06F17/2247 ,  G06F17/2725 ,  G06F17/30637 ,  G06F17/30657 ,  G06Q40/02 ,  G06Q40/025 ,  G06Q40/06 ,  G06Q40/08

    Abstract: A system that may be used to generate documents, where the system is accessible from and integratable with remote systems is provided. A document generation system that may be provided as a service, in the sense that the system may be accessed via, e.g., the Internet, from remote systems such as credit aggregators. The system takes in information regarding the requirements (e.g., type of transaction, number of parties, amount of loan, price, governing law, etc.) of the document needed (e.g., a loan application, construction contract, etc.) and produces an appropriate form based on the input information. It should be noted that access to the document generation system is effectuated by an Internet/network connection via, e.g., a partner provider system such as a DMS, a traditional credit aggregator, a credit aggregator portal, etc. Electronic signature and secure archiving may be provided for generated documents.

    Abstract translation: 提供了可用于生成文档的系统，其中系统可从远程系统访问并与其集成。 在可以通过例如因特网从远程系统例如信用聚合器访问系统的意义上，作为服务提供的文档生成系统。 该系统收集所需文件（例如，贷款申请，建筑合同等）的要求（例如交易类型，当事人数量，贷款额，价格，管理法等）的信息，并生成 基于输入信息的适当形式。 应当注意，通过诸如DMS，合作伙伴提供商系统，传统信用聚合器，信用聚合门户等的互联网/网络连接来实现对文档生成系统的访问。电子签名和安全归档可以 为生成的文档提供。

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