公开(公告)号：US20150191688A1

公开(公告)日：2015-07-09

申请号：US14422565

申请日：2013-03-15

Applicant: Presodemt and Fellows of Harvard College

Inventor： Hongkun Park ,  Alexander K. Shalek ,  Ruihua Ding ,  Joseph Park

IPC: C12M1/32 ,  C12M1/12 ,  C12N5/00 ,  C12N1/20

CPC classification number: B81C1/00111 ,  B01L3/5085 ,  B01L99/00 ,  B01L2300/0851 ,  B01L2300/0896 ,  B01L2300/163 ,  B01L2400/086 ,  B81B7/04 ,  B81B2201/055 ,  B81B2203/0361 ,  B81B2207/056 ,  B82Y15/00 ,  B82Y30/00 ,  C12M23/12 ,  C12M25/00 ,  C12N1/20 ,  C12N5/0068 ,  Y10T156/10

Abstract: The present invention generally relates to nanowires and, in particular, to multiwell plates comprising nanowires, including systems and methods of making the same. Such multiwell plates can, in some cases, be used in automated equipment or high-throughput applications. For example, a plurality of cells may be placed in at least some of the wells of the multiwell plate, and one or more nanowires may be inserted into at least some of the cells within the wells of the multiwell plate. In some cases, one or more of the nanowires may have coated thereon a biological effector. The cells in each of the wells may be identical or different, and/or the biological effector may the same or different. Such multiwell plates may be used, for example, to test a biological effector against a variety of cell types, or to test a variety of biological effectors against a one or more cell types, or the like.

Abstract translation: 本发明一般涉及纳米线，特别涉及包含纳米线的多孔板，包括其制备方法和系统。 在某些情况下，这种多孔板可用于自动化设备或高通量应用中。 例如，可以将多个细胞放置在多孔板的至少一些孔中，并且一个或多个纳米线可以插入到多孔板的孔内的至少一些细胞中。 在一些情况下，一个或多个纳米线可以在其上涂覆有生物效应物。 每个孔中的细胞可以相同或不同，和/或生物效应物可以相同或不同。 这样的多孔板可以用于例如针对各种细胞类型测试生物效应物，或者针对一种或多种细胞类型等测试各种生物效应物。