公开(公告)号：US20240369404A1

公开(公告)日：2024-11-07

申请号：US18651161

申请日：2024-04-30

Applicant: Purdue Research Foundation

Inventor： Vladimir M. SHALAEV ,  Alexandra BOLTASSEVA ,  Colton B. FRUHLING ,  Mustafa Goksu OZLU

IPC: G01J1/04 ,  G01J1/44 ,  H04N25/71 ,  H04N25/76

Abstract: A streak camera is disclosed which includes an entrance slit forming a first end of the streak camera, the entrance slit having a width and height, an image capture device forming a second send of the streak camera, and an epsilon-near-zero (ENZ) slab defined by a bandgap energy and plasma frequency disposed within the streak camera, the ENZ slab configured to receive two beams with a predetermined delay therebetween, the two beams include i) a witness beam through the entrance slit at an incident angle θ, and ii) a trigger beam at substantially a normal incident angle, wherein the trigger beam applies energy at a level below the bandgap energy of the ENZ slab to thereby modify refractive index of the ENZ slab, and thus generate a modified witness beam at a time-varying exit angle φ(t) onto the image capture device.

公开(公告)号：US20160120978A1

公开(公告)日：2016-05-05

申请号：US14896493

申请日：2014-05-23

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Urcan GULER ,  Alexander KILDISHEV ,  Gururaj NAIK ,  Alexandra BOLTASSEVA ,  Vladimir M. SHALAEV

IPC: A61K41/00 ,  A61K9/51 ,  A61K9/00 ,  A61N5/06 ,  A61K47/48

CPC classification number: A61K41/0052 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/5115 ,  A61K47/6905 ,  A61K47/6923 ,  A61K47/6929 ,  A61N5/062 ,  A61N5/0625 ,  A61N2005/0643

Abstract: Disclosed herein are nanoparticle-based plasmonic solutions to therapeutic applications employing titanium nitride (TiN) and other non-stoichiometric compounds as the plasmonic material. Current solutions are suboptimal because they require complex shapes, large particle sizes, and a narrow range of sizes, in order to achieve plasmonic resonances in the biological window. The nanoparticles discloses herein provide plasmonic resonances occurring in the biological window even with small sizes, simple shapes, and better size dispersion restrictions. Local heating efficiencies of such nanoparticles outperform currently used Au and transition metal nanoparticles. The use of smaller particles with simpler shapes and better heating efficiencies allows better diffusion properties into tumor regions, larger penetration depth of light into the biological tissue, and the ability to use excitation light of less power.

Abstract translation: 本文公开了使用氮化钛（TiN）和其它非化学计量化合物作为等离子体激元材料的治疗应用的基于纳米颗粒的等离子体溶液。 目前的解决方案不是最佳的，因为它们需要复杂的形状，大的粒径和窄的尺寸范围，以便在生物窗口中实现等离子体激元共振。 本文公开的纳米颗粒提供了即使具有小尺寸，简单形状和更好的尺寸分散限制的生物窗口中出现的等离子体共振。 这种纳米颗粒的局部加热效率优于当前使用的Au和过渡金属纳米颗粒。 使用具有更简单形状和更好加热效率的较小颗粒允许对肿瘤区域的更好的扩散性质，进入生物组织的较大的穿透深度以及使用较少功率的激发光的能力。