公开(公告)号：US20210207013A1

公开(公告)日：2021-07-08

申请号：US17270095

申请日：2019-08-22

Applicant: Purdue Research Foundation

Inventor： Julie C. Liu ,  Sydney E. Hollingshead ,  Charng-yu Lin ,  Jonathan J. Wilker

IPC: C09J189/00 ,  C07K14/78 ,  A61L24/10 ,  C09J11/04

Abstract: This invention relates to protein-based adhesives that are capable to adhere to a substrate in a dry, wet, moist, or an aqueous environment. Particularly, said adhesives comprise a crosslinking agent and an elastin-like polypeptide (ELP) that contain tyrosine, lysine, cysteine, dihydroxyphenylalanine (DOPA) or trihydroxyphenylalanine (TOPA) amino acid residue, or a combination thereof, on the polypeptide chain of said ELP. Among others, the adhesives disclosed herein may find broad applications in medical treatments and surgical operations. Compositions and methods of use are within the scope of this application.