公开(公告)号：US11793982B2

公开(公告)日：2023-10-24

申请号：US17344362

申请日：2021-06-10

Applicant: Purdue Research Foundation ,  Industry-University Cooperation Foundation Hanyang University

Inventor： Chi Hwan Lee ,  Yoon Yeo ,  Dong Rip Kim

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2205/0244

Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.

公开(公告)号：US20210353923A1

公开(公告)日：2021-11-18

申请号：US17277427

申请日：2019-09-27

Applicant: Purdue Research Foundation

Inventor： Chi Hwan Lee ,  Dong Rip Kim

IPC: A61M37/00

Abstract: Devices for intracellular and intratissue nanoinjection of biomolecules into a living body and methods of producing the devices. Such a device includes a flexible substrate and nanoneedles extending from a surface of the flexible substrate, and can be produced by providing a first substrate having pillars extending from a surface thereof, locally reducing diameters of the pillars at locations thereof adjacent the first substrate, embedding distal ends of the pillars in a flexible substrate, and sufficiently expanding the flexible substrate to cause the pillars to fracture at the locations thereof adjacent the first substrate and detach therefrom to define nanoneedles extending from the flexible substrate.

公开(公告)号：US20210386986A1

公开(公告)日：2021-12-16

申请号：US17344362

申请日：2021-06-10

Applicant: Purdue Research Foundation ,  Industry University Cooperation Foundation Hanyang Universiity

Inventor： Chi Hwan Lee ,  Yoon Yeo ,  Dong Rip Kim

IPC: A61M37/00

Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.