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公开(公告)号:US11793982B2
公开(公告)日:2023-10-24
申请号:US17344362
申请日:2021-06-10
Applicant: Purdue Research Foundation , Industry-University Cooperation Foundation Hanyang University
Inventor: Chi Hwan Lee , Yoon Yeo , Dong Rip Kim
IPC: A61M37/00
CPC classification number: A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2205/0244
Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.
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公开(公告)号:US20210353923A1
公开(公告)日:2021-11-18
申请号:US17277427
申请日:2019-09-27
Applicant: Purdue Research Foundation
Inventor: Chi Hwan Lee , Dong Rip Kim
IPC: A61M37/00
Abstract: Devices for intracellular and intratissue nanoinjection of biomolecules into a living body and methods of producing the devices. Such a device includes a flexible substrate and nanoneedles extending from a surface of the flexible substrate, and can be produced by providing a first substrate having pillars extending from a surface thereof, locally reducing diameters of the pillars at locations thereof adjacent the first substrate, embedding distal ends of the pillars in a flexible substrate, and sufficiently expanding the flexible substrate to cause the pillars to fracture at the locations thereof adjacent the first substrate and detach therefrom to define nanoneedles extending from the flexible substrate.
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公开(公告)号:US20250000419A1
公开(公告)日:2025-01-02
申请号:US18830853
申请日:2024-09-11
Applicant: Purdue Research Foundation
Inventor: Chi Hwan Lee , Georgia Malandraki
IPC: A61B5/282 , A61B5/00 , A61B5/01 , A61B5/145 , A61B5/256 , A61B5/296 , A61B90/00 , A61F7/00 , A61M35/00 , A61M37/00
Abstract: Skin-mountable electronic devices and methods suitable for fabricating and using the devices. One embodiment of such a device includes a flexible structure comprising a pattern of individual interconnected traces each comprising a portion of an electrically-conductive layer that overlies and directly contacts an underlying portion of an elastomeric layer. At least some of the portions of the electrically-conductive layer within the pattern are functional electrodes of the skin-mountable electronic device.
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公开(公告)号:US11518675B2
公开(公告)日:2022-12-06
申请号:US17126316
申请日:2020-12-18
Applicant: Purdue Research Foundation
Inventor: Chi Hwan Lee , Zahyun Ku , Augustine Michael Urbas , Bongjoong Kim
Abstract: Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate.
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公开(公告)号:US20220223457A1
公开(公告)日:2022-07-14
申请号:US17613804
申请日:2020-05-29
Applicant: Purdue Research Foundation
Inventor: Chi Hwan Lee
Abstract: Interfacial delamination processes for physically separating a film structure from a substrate, and processes of fabricating a thin-film electronic device. The processes entail providing the substrate with an electrically-conductive separation layer on a surface of the substrate and optionally providing a pin hole free barrier layer on the electrically-conductive separation layer, forming a film structure on the electrically-conductive separation layer or, if present, the barrier layer, to yield a multilayer structure, and separating the film structure from the substrate by subjecting the multilayer structure to interfacial debonding that comprises contacting at least an interface between the film structure and the electrically-conductive separation layer or, if present, the barrier layer, with water or an electrolyte solution.
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公开(公告)号:US20240367398A1
公开(公告)日:2024-11-07
申请号:US18048596
申请日:2022-10-21
Applicant: Purdue Research Foundation
Inventor: Chi Hwan Lee , Bongjoong Kim , Zahyun Ku , Augustine Urbas , Jehwan Hwang
Abstract: Methods of fabricating infrared bandpass filters and infrared bandpass filters fabricated thereby. The methods include forming metallic and dielectric spacer layers on a mold that defines nanoscale-sized recesses or protuberances, depositing a stress-absorbing layer on the dielectric spacer layer opposite the mold, and applying a force to the stress-absorbing layer to peel a first intermediate structure comprising the metallic layer, the dielectric spacer layer, and the stress-absorbing layer from the mold. The stress-absorbing layer may be dissolved from the first intermediate structure with a solvent to define a second intermediate structure. The second intermediate structure may be transferred to a receiver substrate to define the IR bandpass filter. The recesses or protuberances of the metallic and dielectric spacer layers are configured to function as quasi-three-dimensional (quasi-3D) plasmonic metal-dielectric hybrid nanostructures.
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公开(公告)号:US11802043B2
公开(公告)日:2023-10-31
申请号:US18061052
申请日:2022-12-02
Applicant: Purdue Research Foundation
Inventor: Chi Hwan Lee , Zahyun Ku , Augustine Michael Urbas , Bongjoong Kim
CPC classification number: B82B3/0014 , G02B5/008 , B82Y30/00 , B82Y40/00 , G02B2207/101
Abstract: Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate.
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公开(公告)号:US20220004026A1
公开(公告)日:2022-01-06
申请号:US17365734
申请日:2021-07-01
Applicant: Purdue Research Foundation
Inventor: Chi Hwan Lee , Bryan William Boudouris
Abstract: A device includes a contact lens, a corneal sensor that includes a circular trace of conduction paths located at or near an outer peripheral edge of the contact lens that surrounds an unobstructed area at a center region of the contact lens, and a connection wire coupled to the corneal sensor and configured to electrically couple to an external data acquisition system. Methods of fabricating the device may include providing a thin device that includes a sensor and a connection wire coupled to the sensor, transferring the sensor to a curvilinear inner surface of a contact lens, feeding the connection wire through the inner surface of the contact lens and out of an outer surface of the contact lens, and performing electrochemical polymerization of a conducting polymer material over the sensor to anchor the sensor to the inner surface of the contact lens.
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公开(公告)号:US20210386986A1
公开(公告)日:2021-12-16
申请号:US17344362
申请日:2021-06-10
Applicant: Purdue Research Foundation , Industry University Cooperation Foundation Hanyang Universiity
Inventor: Chi Hwan Lee , Yoon Yeo , Dong Rip Kim
IPC: A61M37/00
Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.
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公开(公告)号:US11000082B2
公开(公告)日:2021-05-11
申请号:US15902039
申请日:2018-02-22
Applicant: Purdue Research Foundation
Inventor: Chi Hwan Lee , Min Ku Kim
IPC: A61F2/58 , A41D19/00 , A41D1/00 , A41D31/00 , B32B1/00 , B32B25/14 , G01L1/20 , G01L1/22 , A61F2/76 , A61F2/50 , G01K7/16 , G01N27/22
Abstract: Electronic assistive gloves for covering artificial prosthetic or robotic hands. The glove includes a base layer formed to fit on the artificial hand, a plurality of sensors carried by the base layer, and an encapsulation layer covering the base layer and formed of a material that mimics human skin.
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