公开(公告)号：US20230414514A1

公开(公告)日：2023-12-28

申请号：US18134109

申请日：2023-04-13

Applicant: Purdue Research Foundation

Inventor： Luis Solorio ,  Anastasiia Vasiukhina ,  Yoon Yeo ,  Sheryhan F. Gad

IPC: A61K9/16 ,  A61K9/00

CPC classification number: A61K9/1647 ,  A61K9/0073

Abstract: A formulation to deter abuse of a drug by smoking comprising a physical barrier having properties to entrap the drug and thermal degradation products thereof. The physical barrier is in the form of an additive or a polymer network or a combination thereof.

公开(公告)号：US20210030898A1

公开(公告)日：2021-02-04

申请号：US16935308

申请日：2020-07-22

Applicant: Purdue Research Foundation

Inventor： Pavlos P. Vlachos ,  Anastasiia Vasiukhina ,  Luis Solorio

IPC: A61K49/22 ,  A61K47/42

Abstract: The present disclosure relates to a novel nano-droplet composition comprising a fluorocarbon core and a polymeric shell, and the method of using and making the novel nano-droplet composition. The fluorocarbon core and the polymeric shell of the novel nano-droplet form a micelle with a size range of 10-1000 nm. The fluorocarbon core comprises at least one fluorocarbon compound with a formula of CnF2n+2 and n is 5-10. The fluorocarbon compound is substantial in liquid form. And the nano-droplet composition has a temperature profile such that the nano-droplet composition has a temperature range of 20-60° C. throughout a temperature modulation process, and has a temperature of about 37° C. prior to administration to a human, animal, biological cell, or tissue subject.

公开(公告)号：US20250123260A1

公开(公告)日：2025-04-17

申请号：US18913378

申请日：2024-10-11

Applicant: Purdue Research Foundation

Inventor： Luis Solorio ,  Hyowon Lee ,  Angel Guillermo Enriquez ,  Madison Mckensi Howard ,  Chun-Wei Hsu ,  Sarah Libring

IPC: G01N33/483 ,  G01N3/04 ,  G01N3/06 ,  G01N3/08

Abstract: A tissue stretching system includes a motor, a first pillar, a second pillar, a force sensor, and an imaging device. The tissue stretching system may be provided as a 2D axial tissue stretcher that may monitor changes in mechanical properties over time. Tissues may be coated onto the first pillar and/or the second pillar. In a specific example, the first pillar and/or the second pillar may be a PDMS (Polydimethylsiloxane) structure configured to probe the mechanical properties in between a designed gap of the first pillar and the second pillar. The motor of the tissue stretching system includes a microcontroller. The motor of the tissue stretching system may have high resolution capabilities to provide the appropriate strain to the sample. The tissue stretching system then determines the actual amount of strain applied to the sample.

公开(公告)号：US11918661B2

公开(公告)日：2024-03-05

申请号：US16935308

申请日：2020-07-22

Applicant: Purdue Research Foundation

Inventor： Pavlos P Vlachos ,  Anastasiia Vasiukhina ,  Luis Solorio

IPC: A61K49/22 ,  A61K47/42

CPC classification number: A61K49/227 ,  A61K47/42 ,  A61K49/221

Abstract: The present disclosure relates to a novel nano-droplet composition comprising a fluorocarbon core and a polymeric shell, and the method of using and making the novel nano-droplet composition. The fluorocarbon core and the polymeric shell of the novel nano-droplet form a micelle with a size range of 10-1000 nm. The fluorocarbon core comprises at least one fluorocarbon compound with a formula of CnF2n+2 and n is 5-10. The fluorocarbon compound is substantial in liquid form. And the nano-droplet composition has a temperature profile such that the nano-droplet composition has a temperature range of 20-60° C. throughout a temperature modulation process, and has a temperature of about 37° C. prior to administration to a human, animal, biological cell, or tissue subject.

公开(公告)号：US20210040427A1

公开(公告)日：2021-02-11

申请号：US16936119

申请日：2020-07-22

Applicant: Purdue Research Foundation

Inventor： Hyowon Lee ,  Hyunsu Park ,  Luis Solorio ,  Angel Enriquez ,  Sarah Libring

IPC: C12M1/32 ,  C12M3/00 ,  C12M1/36 ,  C12M1/42 ,  C12M1/12 ,  C12N5/00 ,  C12N5/071

Abstract: Cell-culture platforms are described that can impart cyclic strain on a biologically-relevant culture substrate. Accordingly, systems and methods of the invention can provide a more accurate model of physiological strain and forces than earlier technologies. Systems of the invention enable high-throughput experimentation in standard culturing equipment, while utilizing a 3D physiologically-relevant environment.