公开(公告)号：US20140056809A1

公开(公告)日：2014-02-27

申请号：US13795059

申请日：2013-03-12

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Mary J. TURK

IPC: A61K51/04

CPC classification number: A61K51/0482 ,  A61K9/127 ,  A61K47/646 ,  A61K47/6849 ,  A61K51/1027

Abstract: The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula Ab-X where the group Ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis.

Abstract translation: 本发明涉及一种治疗或监测/诊断由活化的巨噬细胞介导的疾病状态的方法。 该方法包括向患有巨噬细胞介导的疾病状态的患者施用有效量的包含通式Ab-X的缀合物或复合物的组合物，其中基团Ab包含能够结合活化的巨噬细胞的配体，以及 当缀合物用于治疗疾病状态时，组X包含免疫原，细胞毒素或能够改变巨噬细胞功能的化合物，并且当所述缀合物用于监测/诊断疾病状态时，X包括 成像剂。 该方法可用于治疗患有选自类风湿性关节炎，溃疡性结肠炎，克罗恩病，炎症，感染，骨髓炎，动脉粥样硬化，器官移植排斥，肺纤维化，结节病和系统性硬化症的疾病的患者。