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公开(公告)号：US20230293497A1
公开(公告)日：2023-09-21
申请号：US17991013
申请日：2022-11-21
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , Sumith A. KULARATNE
IPC: A61K31/426 , C07C323/52 , C07D207/416 , A61K47/54 , A61K49/00 , A61K51/04 , C07K5/08 , A61K31/4745 , A61K31/475 , A61K51/08 , A61K47/64
CPC classification number: A61K31/426 , C07C323/52 , C07D207/416 , A61K47/54 , A61K49/0041 , A61K49/0043 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K47/542 , A61K47/548 , A61K49/0056 , C07K5/08 , A61K31/4745 , A61K31/475 , A61K49/0052 , A61K51/088 , A61K47/64 , A61K47/547
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
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2.发明公开公开(公告)号：US20230248835A1
公开(公告)日：2023-08-10
申请号：US18004656
申请日：2021-07-07
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , John Victor NAPOLEON , Fenghua ZHANG
IPC: A61K47/55 , C07D471/04 , A61P35/00
CPC classification number: A61K47/551 , C07D471/04 , A61P35/00
Abstract: Compounds, including Toll-like receptor (TLR) agonists, e.g., TLR7 and TLR7/8 agonists and their folic acid or pteroyl amino acid conjugates, and use thereof to treat a cancer or a fibrotic disease or disorder; and methods of making conjugates comprising targeting ligands of folic acid receptor and TLR7 and TLR7/8 agonists.
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公开(公告)号：US20140056809A1
公开(公告)日：2014-02-27
申请号：US13795059
申请日：2013-03-12
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , Mary J. TURK
IPC: A61K51/04
CPC classification number: A61K51/0482 , A61K9/127 , A61K47/646 , A61K47/6849 , A61K51/1027
Abstract: The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula Ab-X where the group Ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis.
Abstract translation: 本发明涉及一种治疗或监测/诊断由活化的巨噬细胞介导的疾病状态的方法。 该方法包括向患有巨噬细胞介导的疾病状态的患者施用有效量的包含通式Ab-X的缀合物或复合物的组合物，其中基团Ab包含能够结合活化的巨噬细胞的配体，以及 当缀合物用于治疗疾病状态时，组X包含免疫原，细胞毒素或能够改变巨噬细胞功能的化合物，并且当所述缀合物用于监测/诊断疾病状态时，X包括 成像剂。 该方法可用于治疗患有选自类风湿性关节炎，溃疡性结肠炎，克罗恩病，炎症，感染，骨髓炎，动脉粥样硬化，器官移植排斥，肺纤维化，结节病和系统性硬化症的疾病的患者。
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公开(公告)号：US20240058458A1
公开(公告)日：2024-02-22
申请号：US17905748
申请日：2021-03-05
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , John Victor NAPOLEON , Qian LUO
CPC classification number: A61K47/555 , A61K39/4611 , A61K39/4631 , A61K39/4646 , A61K47/551 , A61K47/558 , A61K47/60 , A61K2239/39
Abstract: Compounds, compositions and methods for reducing off-target toxicity of T cells expressing a chimeric antigen receptor (CAR-T cells) and/or providing enhanced control of CAR-T cell activation, and methods of treating a subject and/or modifying CAR-T cell activity in a subject with cancer.
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公开(公告)号：US20220125958A1
公开(公告)日：2022-04-28
申请号：US17488810
申请日：2021-09-29
Applicant: Endocyte, Inc. , Purdue Research Foundation
Inventor： Iontcho R. VLAHOV , Christopher P. LEAMON , Philip S. LOW , Garth L. PARHAM , Quinshou CHEN
IPC: A61K51/04
Abstract: Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.
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Patent Agency Ranking
公开(公告)号：US20190076538A1
公开(公告)日：2019-03-14
申请号：US16105734
申请日：2018-08-20
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , Charity WAYUA
IPC: A61K47/54 , A61K51/02 , A61K49/00 , A61K38/08 , A61K38/07 , C07D405/12 , A61K31/475 , A61K31/4409 , A61K51/04 , C07D243/12 , A61K38/06
Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.
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公开(公告)号：US20170258923A1
公开(公告)日：2017-09-14
申请号：US15606913
申请日：2017-05-26
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , Sumith A. KULARATNE
IPC: A61K31/4745 , A61K51/04 , C07K5/08 , A61K31/426 , C07D207/416 , A61K31/475 , A61K51/08 , A61K49/00 , C07C323/52
CPC classification number: A61K47/64 , A61K31/426 , A61K31/4745 , A61K31/475 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
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公开(公告)号：US20160067341A1
公开(公告)日：2016-03-10
申请号：US14794482
申请日：2015-11-23
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , Sumith A. KULARATNE
IPC: A61K47/48 , A61K31/475 , A61K51/08 , A61K31/4745 , A61K31/426 , A61K49/00
CPC classification number: A61K47/64 , A61K31/426 , A61K31/4745 , A61K31/475 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
Abstract translation: 本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。
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公开(公告)号：US20250144195A1
公开(公告)日：2025-05-08
申请号：US18915595
申请日：2024-10-15
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , Haiyan Chu , Yong Gu Lee
Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.
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公开(公告)号：US20250127939A1
公开(公告)日：2025-04-24
申请号：US18913734
申请日：2024-10-11
Applicant: Endocyte, Inc. , Purdue Research Foundation
Inventor： Iontcho R. VLAHOV , Christopher P. LEAMON , Philip S. LOW , Garth L. PARHAM , Qingshou CHEN
IPC: A61K51/04
Abstract: Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography.
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