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公开(公告)号:US20220055034A1
公开(公告)日:2022-02-24
申请号:US17512282
申请日:2021-10-27
Applicant: Purdue Research Foundation
Inventor: Cagri A. Savran , Chun-Li Chang , Wanfeng Huang , Onur Gur , Rohil Jain
Abstract: Microfluidic systems and methods are described for capturing magnetic target entities bound to one or more magnetic beads. The systems include a well array device that includes a substrate with a surface that has a plurality of wells arranged in one or more arrays on the surface. A first array of wells is arranged adjacent to a first location on the surface. A second and subsequent arrays, if present, are arranged sequentially on the surface at second and subsequent locations. When a liquid sample is added onto the substrate and caused to flow, the liquid sample will flow across the first array first and then flow across the second and subsequent arrays in sequential order. The wells in the first array each have a size that permits entry of only one target entity into the well and each well in the first array has approximately the same size.
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公开(公告)号:US20210380934A1
公开(公告)日:2021-12-09
申请号:US17225708
申请日:2021-04-08
Applicant: Purdue Research Foundation
Inventor: Cagri A. Savran , Rohil Jain , Chun-Li Chang
Abstract: The application relates to methods and systems for culturing individually selected cells in relative isolation from the rest of a population of cells, under physiologically relevant and controllable environmental conditions that can be designed to mimic specific environments, e.g., within a human body.
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公开(公告)号:US11173488B2
公开(公告)日:2021-11-16
申请号:US16095648
申请日:2017-04-24
Applicant: Purdue Research Foundation
Inventor: Cagri A. Savran , Chun-Li Chang , Wanfeng Huang , Onur Gur , Rohil Jain
Abstract: Microfluidic systems and methods are described for capturing magnetic target entities bound to one or more magnetic beads. The systems include a well array device that includes a substrate with a surface that has a plurality of wells arranged in one or more arrays on the surface. A first array of wells is arranged adjacent to a first location on the surface. A second and subsequent arrays, if present, are arranged sequentially on the surface at second and subsequent locations. When a liquid sample is added onto the substrate and caused to flow, the liquid sample will flow across the first array first and then flow across the second and subsequent arrays in sequential order. The wells in the first array each have a size that permits entry of only one target entity into the well and each well in the first array has approximately the same size.
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