公开(公告)号：US20220064586A1

公开(公告)日：2022-03-03

申请号：US17466048

申请日：2021-09-03

Applicant: Purdue Research Foundation

Inventor： Shelley A. Claridge ,  Tyson C. Davis ,  Sarah Calve ,  Alita Miller ,  Anamika Singh

IPC: C12N1/04 ,  C12M1/12 ,  C12M1/00 ,  C12N5/00

Abstract: This present disclosure relates to a designed material surface mimicking properties of an extracellular matrix or matrisome, as a means for modulating cell adhesion, spreading, proliferation, differentiation, or reprogramming; and for controllable, directional cell adhesion, spreading, proliferation, differentiation, or reprogramming. In particular, this present disclosure relates to a designed material surface mimicking properties of large polysaccharides for modulating cell adhesion, proliferation, differentiation, or reprogramming of a cell, and to materials for scaffolding cell growth. Processes and composition matters are within the scope of this patent application.

公开(公告)号：US11193042B2

公开(公告)日：2021-12-07

申请号：US16820786

申请日：2020-03-17

Applicant: Purdue Research Foundation

Inventor： Shelley A. Claridge ,  Tyson C. Davis

IPC: C09D191/00 ,  B05D1/28

Abstract: The present invention generally relates to a method for creating a chemically structured surface with structural elements as small as 1 nm, on a material that does not itself display a high degree of ordering, using thin molecular layers that minimize the material added through the coating. In particular, the present invention discloses a method for assembling a chemical pattern on a surface, comprising pattern elements with scales that can be as small as 1 nm, and then transferring that pattern to another substrate, on which the pattern would not form natively. In the described method, the patterned monolayer is comprised of polymerizable amphiphiles such as diyne phospholipids or diynoic acids, which are transferred from the ordering substrate using a transferring material such as poly(dimethylsiloxane).