公开(公告)号：US20220146522A1

公开(公告)日：2022-05-12

申请号：US17502320

申请日：2021-10-15

Applicant: Purdue Research Foundation

Inventor： Joseph Irudayaraj ,  Wen Ren

IPC: G01N33/58 ,  B01L3/00 ,  G01N33/52 ,  G01N33/569 ,  G01N33/558

Abstract: The present disclosure relates to a novel method for lateral flow immunoassay (LFIA) by utilizing plasmonic enhancement strategy. More specifically, the present disclosure provides a plasmonic enhanced lateral flow sensor (pLFS) concept by introducing a liposome-based amplification of the colorimetric signals on the lateral flow platform for ultrasensitive detection of pathogens.

公开(公告)号：US12031983B2

公开(公告)日：2024-07-09

申请号：US17502320

申请日：2021-10-15

Applicant: Purdue Research Foundation

Inventor： Joseph Irudayaraj ,  Wen Ren

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/52 ,  G01N33/569 ,  G01N33/58

CPC classification number: G01N33/54388 ,  B01L3/5023 ,  G01N33/521 ,  G01N33/56916 ,  G01N33/586 ,  G01N33/587

Abstract: The present disclosure relates to a novel method for lateral flow immunoassay (LFIA) by utilizing plasmonic enhancement strategy. More specifically, the present disclosure provides a plasmonic enhanced lateral flow sensor (pLFS) concept by introducing a liposome-based amplification of the colorimetric signals on the lateral flow platform for ultrasensitive detection of pathogens.

公开(公告)号：US11761958B2

公开(公告)日：2023-09-19

申请号：US16305731

申请日：2017-07-12

Applicant: Purdue Research Foundation

Inventor： Joseph M K Irudayaraj ,  Wen Ren

IPC: G01N33/543 ,  G01N21/78 ,  G01N33/569 ,  G01N33/574

CPC classification number: G01N33/54388 ,  G01N21/78 ,  G01N33/54326 ,  G01N33/56911 ,  G01N33/57411

Abstract: Devices, systems, and methods are provided for magnetic focus enhanced lateral flow assays. The devices and systems are ultrasensitive and provide for the visual detection of the presence or absence of one or more target analytes—which may include pathogens, proteins, or even molecules smaller than the foregoing—even when such analytes are only present in very limited amounts. The devices and systems include an immunostrip with a magnet positioned adjacent thereto, and magnetic probes specific to a target analyte that bind to the target analyte with specificity if present within a fluid sample to be tested. Methods are also provided for detecting one or more target analytes using magnetic focus, such methods including a step of controlling movement of a target analyte complex on an immunostrip incorporating a magnetic field, where such control slows a flow of the target analyte complex through a capture area on the immunostrip.

公开(公告)号：US20240337654A1

公开(公告)日：2024-10-10

申请号：US18749553

申请日：2024-06-20

Applicant: Purdue Research Foundation

Inventor： Joseph Irudayaraj ,  Wen Ren

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/52 ,  G01N33/569 ,  G01N33/58

CPC classification number: G01N33/54388 ,  B01L3/5023 ,  G01N33/521 ,  G01N33/56916 ,  G01N33/586 ,  G01N33/587

Abstract: The present disclosure relates to a novel method for lateral flow immunoassay (LFIA) by utilizing plasmonic enhancement strategy. More specifically, the present disclosure provides a plasmonic enhanced lateral flow sensor (pLFS) concept by introducing a liposome-based amplification of the colorimetric signals on the lateral flow platform for ultrasensitive detection of pathogens.