公开(公告)号：US20210393786A1

公开(公告)日：2021-12-23

申请号：US17263451

申请日：2019-07-20

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Xin Liu

IPC: A61K47/55 ,  A61K47/54 ,  A61K51/04 ,  A61K49/00

Abstract: Disclosed herein is a small molecule targeted drug conjugate for anti-influenza chemotherapy and immunotherapy. The disclosed drug conjugate may form an adaptor to recruit additional CAR T cells or other immune cells for precise elimination of influenza virus-infected cells in a subject. Concurrently administered antibodies or pre-existing immunity in influenza-virus infected subject works well with the targeted conjugate to eliminate virus infected cells, saving valuable time for rescuing late stage patients.