公开(公告)号：US20160363560A9

公开(公告)日：2016-12-15

申请号：US14167270

申请日：2014-01-29

Applicant: Purdue Research Foundation

Inventor： M. Daniel Raftery ,  Jian Zhang ,  Zane Hammoud

IPC: G01N27/74

CPC classification number: G01N27/74 ,  G01N33/57488 ,  G01N2570/00

Abstract: Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HGD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HGD), which are widely regarded as precursors of EAC.

Abstract translation: 公开了使用小分子代谢物生物标志物的小组或小组检测和筛选食管腺癌（EAC）患者和用于监测EAC治疗的方法。 在其他方面，公开了用于检测和筛选高危条件（BE和HGD）进展到EAC以及使用小分子代谢物生物标志物的小组或小组进行监测的方法。 生物标志物对EAC的检测敏感且特异，也可用于对Barrett食管（BE）和高度发育异常（HGD）进行分类，被广泛认为是EAC的前体。

公开(公告)号：US20140148349A1

公开(公告)日：2014-05-29

申请号：US14167270

申请日：2014-01-29

Applicant: Purdue Research Foundation

Inventor： M. Daniel Raftery ,  Jian Zhang ,  Zane Hammoud

IPC: G01N27/74

CPC classification number: G01N27/74 ,  G01N33/57488 ,  G01N2570/00

Abstract: Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HGD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HGD), which are widely regarded as precursors of EAC.

Abstract translation: 公开了使用小分子代谢物生物标志物的小组或小组检测和筛选食管腺癌（EAC）患者和用于监测EAC治疗的方法。 在其他方面，公开了用于检测和筛选高危条件（BE和HGD）进展到EAC以及使用小分子代谢物生物标志物的小组或小组进行监测的方法。 生物标志物对EAC的检测敏感且特异，也可用于对Barrett食管（BE）和高度发育异常（HGD）进行分类，被广泛认为是EAC的前体。