公开(公告)号：US20230311096A1

公开(公告)日：2023-10-05

申请号：US17860405

申请日：2022-07-08

Applicant: Qingdao University of Science and Technology

Inventor： Yinglong WANG ,  Peizhe CUI ,  Zhaoyou ZHU ,  Fanqing MENG ,  Xin LI ,  Jianguang QI ,  Limei ZHONG ,  Deping DU ,  Bingkun XIA ,  Jianbo JIA ,  Zuxing KOU

IPC: B01J23/06 ,  B01J20/20 ,  B01J35/06 ,  B01J35/00 ,  B01J35/02 ,  B01J37/02 ,  B01J37/08 ,  C07C51/347

CPC classification number: B01J23/06 ,  B01J20/20 ,  B01J35/0013 ,  B01J35/023 ,  B01J35/06 ,  B01J37/0217 ,  B01J37/0228 ,  B01J37/0236 ,  B01J37/088 ,  C07C51/347

Abstract: The present disclosure provides an active zinc-based catalyst and a preparation method thereof, and use in catalyzing a rearrangement reaction of ibuprofen. The active zinc-based catalyst includes a carbon-based fiber material and nano-zinc oxide supported on a fiber surface of the carbon-based fiber material. The active zinc-based catalyst is introduced with the carbon-based fiber material, and the carbon-based fiber material is capable of increasing a specific surface area of the catalyst, thereby improving a dispersion degree of zinc oxide, increasing the number of catalytic active sites, and significantly improving a catalytic activity. Meanwhile, due to a certain mechanical strength, the carbon-based fiber material is capable of improving a mechanical strength of the catalyst, making the catalyst exist stably in ketal fluid, maintaining a stable morphology of the catalyst, and avoiding or inhibiting reduction of the catalytic active sites, thereby ensuring a catalytic stability.

公开(公告)号：US20230391686A1

公开(公告)日：2023-12-07

申请号：US18229220

申请日：2023-08-02

Applicant: Qingdao University of Science and Technology

Inventor： Peizhe CUI ,  Jianguang QI ,  Wenhui XU ,  Yinglong WANG ,  Zhaoyou ZHU ,  Kaiguang WANG ,  Xin LI ,  Fanqing MENG ,  Limei ZHONG ,  Shuli YIN ,  Lei HAN ,  Jianbo JIA ,  Zhonghui ZHENG

IPC: C07C2/54 ,  B01J8/00 ,  B01J8/08

CPC classification number: C07C2/54 ,  B01J8/0015 ,  B01J8/085 ,  B01J2208/00168 ,  B01J2208/00769

Abstract: A process and a device for continuous flow side-chain alkylation which relate to the technical field of organic synthesis. In this process and the device for continuous flow side-chain alkylation, an ibuprofen raw material is prepared with alkylbenzene as a raw material. This raw material alkylbenzene is easily available and has a low cost, and is suitable for scale-up production. Moreover, an entire preparation process adopts continuous chemical synthesis, and a reaction time of each stage can be precisely controlled, which is beneficial to control a total reaction time and reduce an amount of impurities produced. In this way, a purity and a yield of the ibuprofen raw material are improved. In summary, a continuous synthesis method for side-chain alkylation of alkylbenzene provided by the present disclosure shows a low cost and a high yield.