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公开(公告)号：US20200209256A1
公开(公告)日：2020-07-02
申请号：US16709052
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20200219590A1
公开(公告)日：2020-07-09
申请号：US16686028
申请日：2019-11-15
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
IPC: G16B50/30 , G16B25/10 , G16B40/00 , C12Q1/6806
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20200209253A1
公开(公告)日：2020-07-02
申请号：US16708956
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20200209254A1
公开(公告)日：2020-07-02
申请号：US16708989
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
IPC: G01N33/68
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20200209249A1
公开(公告)日：2020-07-02
申请号：US16709103
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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Patent Agency Ranking
公开(公告)号：US20200031861A1
公开(公告)日：2020-01-30
申请号：US16510794
申请日：2019-07-12
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jeremy Lackey , Roger Nani , David Dodd
Abstract: Aspects of the disclosure provide biconjugatable labels, labeled biomolecules, and methods of using and making the same.
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公开(公告)号：US20170362651A1
公开(公告)日：2017-12-21
申请号：US15600979
申请日：2017-05-22
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jeremy Lackey , Brian Reed , Xinghua Shi , Haidong Huang , David Dodd
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C07H21/00 , C12Q1/6816 , C12Q2525/101 , C12Q2525/197 , C12Q2525/301 , C12Q2563/103
Abstract: Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided. In some aspects, methods of sequencing nucleic acids involve determining the luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently labeled nucleotides incorporated during a nucleic acid sequencing reaction. In some aspects, the disclosure provides compositions comprising luminescently labeled nucleotides.
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公开(公告)号：US20240068027A1
公开(公告)日：2024-02-29
申请号：US18188122
申请日：2023-03-22
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jeremy Lackey , Brian Reed , Xinghua Shi , Haidong Huang , David Dodd
IPC: C12Q1/6876 , C07H19/073 , C07H19/173 , C07H21/04 , C12Q1/6806 , C12Q1/6816
CPC classification number: C12Q1/6876 , C07H19/073 , C07H19/173 , C07H21/04 , C12Q1/6806 , C12Q1/6816 , C12Q1/6869
Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
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公开(公告)号：US11655504B2
公开(公告)日：2023-05-23
申请号：US16043547
申请日：2018-07-24
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jeremy Lackey , Brian Reed , Xinghua Shi , Haidong Huang , David Dodd
IPC: C12Q1/6876 , C12Q1/6816 , C12Q1/6806 , C07H19/073 , C07H21/04 , C07H19/173 , C12Q1/6869
CPC classification number: C12Q1/6876 , C07H19/073 , C07H19/173 , C07H21/04 , C12Q1/6806 , C12Q1/6816 , C12Q1/6869 , C12Q2525/185 , C12Q2525/197 , C12Q2525/313 , C12Q2563/103 , C12Q2600/16 , C12Q1/6869 , C12Q2525/197 , C12Q2563/103 , C12Q2565/102 , C12Q1/6869 , C12Q2525/197 , C12Q2563/107 , C12Q2565/102
Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
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公开(公告)号：US11613772B2
公开(公告)日：2023-03-28
申请号：US16751138
申请日：2020-01-23
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jeremy Lackey , Brian Reed , Xinghua Shi , Haidong Huang , David Dodd
IPC: C12Q1/68 , G01N21/64 , C12Q1/6818 , C12Q1/6869
Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
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