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1.发明申请OPEN CHAINED OR FUSED 1,1 '-ALKYLENE-BIS-URACIL DERIVATIVES, USEFUL IN SKIN UV-PROTECTION 有权开链或熔融1,1' - 亚乙基双 - 尿嘧啶衍生物，有助于皮肤防紫外线公开(公告)号：US20150231051A1
公开(公告)日：2015-08-20
申请号：US14434722
申请日：2013-10-11
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Robert Vince , Abbas Raza , Christine Dreis
IPC: A61K8/49 , C07D487/16 , A61Q17/04 , C07D239/54
CPC classification number: A61K8/4953 , A61Q17/04 , A61Q19/08 , C07D239/54 , C07D487/04 , C07D487/16
Abstract: The invention provides compounds of formula I; or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.
Abstract translation: 本发明提供式I化合物; 或其盐。 本发明还提供包含式I化合物或一种或多种式I化合物的混合物的皮肤病学组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于保护皮肤或DNA免受光损伤的治疗方法或 修复光损伤的皮肤或DNA。
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公开(公告)号：US20170000712A1
公开(公告)日：2017-01-05
申请号：US14901979
申请日：2014-07-02
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Robert Vince , Abbas Raza , Christine Dreis
IPC: A61K8/49 , A61K8/58 , C07D239/54 , A61K8/04 , C07F7/08 , A61K8/11 , A61K8/02 , A61Q19/04 , C07D487/16
CPC classification number: A61K8/4953 , A61K8/0204 , A61K8/046 , A61K8/11 , A61K8/585 , A61K2800/91 , A61Q19/04 , C07D239/52 , C07D239/54 , C07D403/06 , C07D403/12 , C07D487/16 , C07F7/0889
Abstract: The invention provides sunless tanning compositions comprising a compounds of formula (I): or a salt thereof as described herein as well as methods for tanning mammalian skin by contacting the skin with the compounds of formula (I) or compositions comprising compounds of formula (I).
Abstract translation: 本发明提供了包含本文所述的式（I）化合物或其盐的无阳光鞣制组合物，以及通过使皮肤与式（I）化合物或包含式（I）化合物的组合物接触来鞣制哺乳动物皮肤的方法 ）。
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Patent Agency Ranking
3.发明授权Open chained or fused 1,1′-alkylene-bis-uracil derivatives, useful in skin UV-protection 有权开链或融合的1,1'-亚烷基 - 双 - 尿嘧啶衍生物，可用于皮肤紫外线防护公开(公告)号：US09364406B2
公开(公告)日：2016-06-14
申请号：US14434722
申请日：2013-10-11
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Robert Vince , Abbas Raza , Christine Dreis
IPC: C07D487/04 , A61K8/49 , C07D239/54 , C07D487/16 , A61Q17/04
CPC classification number: A61K8/4953 , A61Q17/04 , A61Q19/08 , C07D239/54 , C07D487/04 , C07D487/16
Abstract: The invention provides compounds of formula I; or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.
Abstract translation: 本发明提供式I化合物; 或其盐。 本发明还提供包含式I化合物或一种或多种式I化合物的混合物的皮肤病学组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于保护皮肤或DNA免受光损伤的治疗方法或 修复光损伤的皮肤或DNA。
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公开(公告)号：US09987211B2
公开(公告)日：2018-06-05
申请号：US14901979
申请日：2014-07-02
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Robert Vince , Abbas Raza , Christine Dreis
IPC: A61K8/49 , A61K8/58 , C07D239/54 , A61K8/04 , C07F7/08 , A61K8/11 , A61K8/02 , A61Q19/04 , C07D487/16 , C07D403/12 , C07D403/06 , C07D239/52
CPC classification number: A61K8/4953 , A61K8/0204 , A61K8/046 , A61K8/11 , A61K8/585 , A61K2800/91 , A61Q19/04 , C07D239/52 , C07D239/54 , C07D403/06 , C07D403/12 , C07D487/16 , C07F7/0889
Abstract: The invention provides sunless tanning compositions comprising a compounds of formula (I): or a salt thereof as described herein as well as methods for tanning mammalian skin by contacting the skin with the compounds of formula (I) or compositions comprising compounds of formula (I).
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公开(公告)号：US20140350036A1
公开(公告)日：2014-11-27
申请号：US14371900
申请日：2013-01-11
Applicant: Regents of the University of Minnesota
Inventor： Robert Vince , Abbas Raza , Christine Dreis
IPC: C07D239/22 , C07D487/16 , C07D487/04
CPC classification number: C07D239/22 , A61K8/4953 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/695 , A61K45/06 , A61Q17/04 , A61Q19/004 , C07D403/12 , C07D487/04 , C07D487/16 , A61K2300/00
Abstract: The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.
Abstract translation: 本发明提供了本文所述的式I化合物或其盐。 本发明还提供包含式I化合物或一种或多种式I化合物的混合物的皮肤病学组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于保护皮肤或DNA免受光损伤的治疗方法或 修复光损伤的皮肤或DNA。
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公开(公告)号：US11479579B2
公开(公告)日：2022-10-25
申请号：US17256421
申请日：2019-07-01
Applicant: Regents of the University of Minnesota
Inventor： Robert Vince , Swati Sudhakar More , Abbas Raza
Abstract: Disclosed herein are compounds of formula I: (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 may any of the values defined herein, as well as compositions comprising such compounds. Also disclosed are methods for treating diseases including neurodegenerative disorders such as Parkinson's Disease and Alzheimer's Disease.
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公开(公告)号：US09403778B2
公开(公告)日：2016-08-02
申请号：US14371900
申请日：2013-01-11
Applicant: Regents of the University of Minnesota
Inventor： Robert Vince , Abbas Raza , Christine Dreis
IPC: C07D239/22 , C07D487/04 , C07D487/16 , C07D403/12 , A61K45/06 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/695 , A61K8/49 , A61Q17/04 , A61Q19/00
CPC classification number: C07D239/22 , A61K8/4953 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/695 , A61K45/06 , A61Q17/04 , A61Q19/004 , C07D403/12 , C07D487/04 , C07D487/16 , A61K2300/00
Abstract: The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.
Abstract translation: 本发明提供了本文所述的式I化合物或其盐。 本发明还提供包含式I化合物或一种或多种式I化合物的混合物的皮肤病学组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于保护皮肤或DNA免受光损伤的治疗方法或 修复光损伤的皮肤或DNA。
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