公开(公告)号：US20170127947A1

公开(公告)日：2017-05-11

申请号：US15243207

申请日：2016-08-22

Applicant: ROBERT R. ALFANO

Inventor： ROBERT ALFANO ,  LINGYAN SHI ,  YURY BUDANSKY

IPC: A61B5/00 ,  G01N21/65

CPC classification number: A61B5/0075 ,  A61B5/0068 ,  G01N21/65 ,  G01N2021/655 ,  G01N2201/0612

Abstract: There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.