公开(公告)号：US20250057451A1

公开(公告)日：2025-02-20

申请号：US18712567

申请日：2022-10-12

Applicant: RSP SYSTEMS A/S

Inventor： Signe Maria LUNDSGAARD-NIELSEN ,  Anders PORS ,  Anders WEBER

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/65

Abstract: A system and method of calibrating a model used in a device for non-invasive in vivo measurement of an analyte concentration using Raman spectroscopy, the device including an optical source for providing an optical signal and an optical detector to receive a Raman scattered optical output, the method including: in response to the laser source being directed to a user's skin gathering Raman scattered radiation from the user's skin and based on that, calibrating the model based on reference data and the received Raman spectra over an extended period of days, such as 10 days or more.

公开(公告)号：US20160287147A1

公开(公告)日：2016-10-06

申请号：US15182455

申请日：2016-06-14

Applicant: RSP SYSTEMS A/S

Inventor： Morten HENNEBERG ,  Stefan Ovesen BANKE ,  Anders WEBER

IPC: A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/441 ,  A61B2562/0238 ,  A61B2562/0242 ,  A61B2562/146 ,  G01N21/65

Abstract: A metabolite concentration is measured in vivo using Raman spectroscopy in such a way as to receive at a detector light scattered from the metabolite in interstitial fluid in skin in a measurement location at a depth of from 200-300 μm below the skin surface providing improved retention of correct calibration and transferability of calibration between individual subjects.

Abstract translation: 使用拉曼光谱法在体内测量代谢物浓度，使得在距离皮肤表面200-300μm深度的测量位置处接收来自皮肤间隙液中的代谢物散射的检测器光，从而提供改善的保留 正确的校准和个体对象之间校准的可转移性。