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    A METHOD AND A CORRESPONDING RADIATION TREATMENT SYSTEM FOR FACILITATING OPTIMIZATION OF A MULTIMODAL RADIATION THERAPY PLAN
    1.
    发明申请
    A METHOD AND A CORRESPONDING RADIATION TREATMENT SYSTEM FOR FACILITATING OPTIMIZATION OF A MULTIMODAL RADIATION THERAPY PLAN 有权

    公开(公告)号：US20210205635A1

    公开(公告)日：2021-07-08

    申请号：US17057170

    申请日：2019-05-27

    Applicant: RaySearch Laboratories AB

    Inventor： Rasmus BOKRANTZ ,  Albin FREDRIKSSON ,  Kjell ERIKSSON ,  Erik ENGWALL ,  Erik TRANEUS

    IPC: A61N5/10

    Abstract: The present disclosure generally relates to the field of radiation treatment. More specifically, the present disclosure generally relates to methods and radiation treatment systems for facilitating a multimodal radiation therapy treatment plan, in particular a multimodal radiation therapy plan employing a combined photon beam and electron beam radiation treatment. According to one example embodiment described in the disclosure, a method may comprise obtaining information related to a set of candidate beam types for the combined photon beam and electron beam radiation treatment; comparing the set of candidate beam types against a selection criterion to establish a subset of beam types from the candidate beam types; and generating the combined photon beam and electron beam radiation treatment plan utilizing the thus established subset of beam types.

    Dynamic estimation of a biological effect of a variable composition of non-photon radiation
    2.
    发明公开
    Dynamic estimation of a biological effect of a variable composition of non-photon radiation 审中-公开

    公开(公告)号：US20230233876A1

    公开(公告)日：2023-07-27

    申请号：US18001297

    申请日：2021-06-14

    Applicant: RAYSEARCH LABORATORIES AB

    Inventor： Rasmus BOKRANTZ ,  Lars GLIMELIUS

    IPC: A61N5/10 ,  G16H50/30

    CPC classification number: A61N5/103 ,  G16H50/30 ,  A61N2005/1087

    Abstract: A method for dynamically estimating a biological effect of a variable combination of non-photon radiation in accordance with a relative biological effectiveness, RBE, model including at least one biological effect multiplier δ(T, E) which depends on particle type T and/or particle energy E, the method comprising:

    obtaining one or more non-photon radiation contributions D(i)(T, E), 1 ≤ i ≤ N, at least one of said contributions including multiple particle types and/or multiple particle energies;
    storing per-contribution dose-weighted averages δ̅(i), 1 ≤ i ≤ N, of said at least one biological effect multiplier with respect to each of the one or more contributions; and
    in response to obtaining an assignment Π of the combination, the assignment being in terms of non-negative coefficients k1, k2, ..., kN ≥ 0 to be applied to the one or more contributions, determining a biological effect of the combination, including computing a combined dose-weighted average δ̅Π of said at least one biological effect multiplier on the basis of the stored per-contribution dose-weighted averages.

    METHOD, COMPUTER PROGRAM AND SYSTEM FOR OPTIMIZING A RADIOTHERAPY TREATMENT PLAN
    5.
    发明申请
    METHOD, COMPUTER PROGRAM AND SYSTEM FOR OPTIMIZING A RADIOTHERAPY TREATMENT PLAN 审中-公开

    公开(公告)号：US20200324143A1

    公开(公告)日：2020-10-15

    申请号：US16091274

    申请日：2017-04-05

    Applicant: RaySearch Laboratories AB

    Inventor： Rasmus BOKRANTZ ,  Albin FREDRIKSSON

    IPC: A61N5/10

    Abstract: A scenario-based treatment plan optimization method for radiotherapy treatment is proposed, in which a first and a second possible scenario are defined. Different optimization functions are defined for the scenarios and the treatment plan is optimized applying the first optimization function under the first scenario and the second optimization function under the second scenario, thereby obtaining a first optimized radiotherapy treatment plan.

    SYSTEM AND METHOD FOR DETERMINING A RADIATION TREATMENT PLAN AND A RADIATION THERAPY MACHINE
    6.
    发明申请
    SYSTEM AND METHOD FOR DETERMINING A RADIATION TREATMENT PLAN AND A RADIATION THERAPY MACHINE 审中-公开

    公开(公告)号：US20170296840A1

    公开(公告)日：2017-10-19

    申请号：US15516091

    申请日：2016-03-30

    Applicant: RaySearch Laboratories AB

    Inventor： Rasmus BOKRANTZ ,  Björn HÅRDEMARK ,  Albin FREDRIKSSON

    IPC: A61N5/10

    CPC classification number: A61N5/103 ,  A61N5/1045

    Abstract: A radiation treatment plan is determined by: [1] receiving a current fluence map defining a radiation dose; [2] receiving a current control-point sequence describing machine settings for a collimator associated with a radiation source; [3] determining an updated fluence map and an updated control-point sequence based on the current fluence map; [4] determining a further updated control-point sequence based on the updated control-point sequence and the updated fluence map; [5] determining a further updated fluence map based on the updated fluence map, the updated control-point sequence and the further updated control-point sequence; [6] checking if a stopping criterion is fulfilled; if so: stopping the process, and producing an output radiation treatment plan based on the further updated control-point sequence; and otherwise: setting the further updated fluence map, or zero, to the current fluence map; setting the further updated control-point sequence to the current control-point sequence; and returning to step [3].

    SYSTEM AND METHOD FOR DETERMINING A RADIATION TREATMENT PLAN AND A RADIATION THERAPY MACHINE
    9.
    发明申请
    SYSTEM AND METHOD FOR DETERMINING A RADIATION TREATMENT PLAN AND A RADIATION THERAPY MACHINE 审中-公开

    公开(公告)号：US20170157423A1

    公开(公告)日：2017-06-08

    申请号：US15367872

    申请日：2016-12-02

    Applicant: RaySearch Laboratories AB

    Inventor： Rasmus BOKRANTZ ,  Björn HÅRDEMARK

    IPC: A61N5/10

    CPC classification number: A61N5/1038 ,  A61N5/103 ,  A61N5/1036 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1071

    Abstract: An output radiation treatment plan for at least one target in a treatment volume is determined. Each target is associated with a prescribed radiation dose. An updated treatment plan causes the prescribed radiation dose to be delivered to the target when implemented by a radiation therapy machine. The updated treatment plan requires an updated delivery time to complete and is calculated by: [i] receiving a numerical value designating an upper bound on modulation efficiency of the updated treatment plan, [ii] receiving a current treatment plan, [iii] calculating a current delivery time for the current treatment plan, [iv] calculating an un-modulated delivery time for the current treatment plan, and [v] calculating the updated treatment plan by executing an optimization process while satisfying the upper bound on the modulation efficiency. Steps [ii] to [v] are traversed a predetermined number of times. Thereafter, the output radiation treatment plan is generated.

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