公开(公告)号：US20190091673A1

公开(公告)日：2019-03-28

申请号：US15745361

申请日：2016-07-15

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Eric STERN ,  Aleksandar VACIC ,  Alec Nathanson FLYER ,  Benjamin SPEARS ,  Susan CLARDY

IPC: B01J31/16 ,  B01J31/18 ,  B01J35/00 ,  C09K11/07 ,  G01N33/58

Abstract: Nanoparticles for use in assay methods for detecting analytes in samples, which comprise a signal inducing agent, e.g. a transition-metal catalyst or a chemiluminophore, a chemiluminophore precursor, a soluble absorber, or a soluble absorber precursor. After binding to an analyte, the nanoparticle is dissociated by a chemical or physical trigger, e.g. an organic solvent or ultrasound, to release the signal inducing agent, which releases a detectable signal via a physical or chemical reaction. The nanoparticles comprising a chemiluminophore, a chemiluminophore precursor, a soluble absorber, or a soluble absorber precursor can also effect chemical reactions that serve as signal amplifiers.