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    ASSAYS AND REAGENTS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING
    1.
    发明申请
    ASSAYS AND REAGENTS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING 审中-公开

    公开(公告)号：US20200040375A1

    公开(公告)日：2020-02-06

    申请号：US16506729

    申请日：2019-07-09

    Applicant: SELUX DIAGNOSTICS, INC.

    Inventor： Benjamin Spears ,  Kelly Flentie

    IPC: C12Q1/18 ,  G01N21/64 ,  G01N33/483

    Abstract: Systems and methods for antimicrobial susceptibility testing (AST) are provided in which variances in anionic charge of microbes are taken into account. Cationic surfactants may be used to sensitize otherwise resistant microorganisms to polycationic antibiotics, such as polymyxins. Since microorganisms gain polycationic antibiotic resistance through mutations that decrease surface anionic charge, the susceptibility of a microorganism to a polycationic antibiotic may be indicative of its surface charge. In order to enable electrostatic interactions with the microorganism surface, a cationic surfactant may be applied to increase the anionic charge of the microorganism.

    METABOLIC ASSAY FOR BACTERIAL GROWTH AND GRAM TYPING
    6.
    发明申请
    METABOLIC ASSAY FOR BACTERIAL GROWTH AND GRAM TYPING 审中-公开

    公开(公告)号：US20190300927A1

    公开(公告)日：2019-10-03

    申请号：US16366244

    申请日：2019-03-27

    Applicant: SELUX DIAGNOSTICS, INC.

    Inventor： Benjamin Spears ,  Eric Stern ,  Kelly Flentie

    IPC: C12Q1/20 ,  C12Q1/08

    Abstract: The use of metabolic probes is well-established for determining cell viability and assessing drug cytotoxicity. Resazurin-based formulations, in particular, have found utility for determining susceptibilities of microorganisms to antimicrobials, specifically through their use in antibiotic susceptibility testing (AST). There is a strong need currently to shorten AST durations, thus resazurin formulations that produce signals earlier are advantageous. This need results from the slow state of clinical microbiology testing, which may leave patients exposed to unnecessary or ineffective broad-spectrum agents for prolonged periods of time. Another slow microbiology test is Gram staining, still most often performed manually in sequential steps. Speeding Gram typing, preferably with an automated platform, would also speed time-to-results and decrease manual workloads on medical technologists in clinical microbiology laboratories.

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